نتایج جستجو برای: 5 رشیدرضا

تعداد نتایج: 1215799  

2011
Aleksandra Szwagierczak Andreas Brachmann Christine S. Schmidt Sebastian Bultmann Heinrich Leonhardt Fabio Spada

In mammalian genomes a sixth base, 5-hydroxymethylcytosine ((hm)C), is generated by enzymatic oxidation of 5-methylcytosine ((m)C). This discovery has raised fundamental questions about the functional relevance of (hm)C in mammalian genomes. Due to their very similar chemical structure, discrimination of the rare (hm)C against the far more abundant (m)C is technically challenging and to date no...

Journal: :Chemical communications 2011
Akiko Nomura Kaori Sugizaki Hiroyuki Yanagisawa Akimitsu Okamoto

An artificial phosphopeptide recognized the difference between methylated and hydroxymethylated cytosines in DNA. The Sp1 zinc finger peptide substituted by phosphotyrosine effectively discriminated between 5-methylcytosine, 5-hydroxymethylcytosine ((hm)C) and unmethylated cytosine. The DNA recognition properties of the peptide differ from those of other chemicals that detect (hm)C.

Journal: :Bulletin of the Chemical Society of Japan 1983

Journal: :Microbiology and Immunology 1991

Journal: :ACS Chemical Neuroscience 2014

Journal: :Journal of Optical Communications 2015

2013
G. Klimke R. Mengel M. J. Robins

Adenosine Analogs, Conformation, NMR The solution conformation of adenosine(/Oribosides modified at the 2', 3' or 5' position is derived from the analysis o f the HRNM R spectra of the ribose protons. The conformational equilibria of the furanoside rings are described by the two state N <-+ S model introduced by Altona and Sundaralingam. The new compounds studied are: 2'-thiobenzoyl-2'-deoxyade...

Journal: :Cytogenetic and genome research 2015
Duo Li Bin Guo Haijing Wu Lina Tan Qianjin Lu

DNA methylation plays an important role in the epigenetic regulation of mammalian gene expression. TET (ten-eleven translocation) proteins, newly discovered demethylases, have sparked great interest since their discovery. TET proteins catalyze 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in 3 consecutive Fe(II)- and 2-oxoglutarate (2-OG)-dependent oxidati...

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

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