In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for...

PURPOSE A 48-hour trial of dexamethasone coanalgesia became our standard practice in May 2008. This is our research Ethics Board-approved review of this experience to date with attention to perioperative narcotics use and pain scores for the first 48 hours after surgery as well as length of stay (LOS), wound healing complications, and infections in the first 6 months, compared with the historic...

Introduction: Glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. Although changes in TNFα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. We investigated the effect of microinfusion of TNFα into the LC in a rat model of neuropathic pain. Methods: Male Wistar rats...

A survey of 65 freestall-housed dairy herds in five different countries, with an average of 1023 milking cows, found that footbaths were used 1-4 times per day for 1-7 days per week, with between 80 and 3000 cows passing through the bath between chemical changes. The most common agents used were copper sulfate (41/65) and formalin (22/65). Twenty-seven herds (42%) used more than one chemical. T...

While it has been shown that TCP Vegas provides better performance compared to TCP Reno, studies have identified various issues associated with the protocol. We propose modifications to the congestion avoidance mechanism of the TCP Vegas to overcome these limitations. Unlike the solutions proposed in the past, our solution, named TCP Vegas-A, is neither dependent on optimising any critical para...

Results Ischemic or dilated cardiomyopathy were the main indications (23(43%) each), age 48+13 years and 48(91%) were male. Transplant listing Status: IA 14(26%)(VAD or 2 inotropes), IB 14(26%)(1 inotrope) and II 25 (47%) (no inotrope). Mean waiting time 70+83 days. Twelve (24%) were transplanted during VAD support (median support: 36 days). Operative technique: orthotopic bicaval transplant wi...

Ovarian torsion during pregnancy is a rare event and occurs mostly the first trimester. This case describing diagnosis management of an ovarian at 33 weeks in twin with normal term delivery. The patient presented irregular uterine contraction due to acute abdominal pain right iliac fossa. A cyst was discovered ultrasound scan on ovary highly suspected. small laparotomy facing mass after guidanc...

OBJECTIVE The post-reconstitution chemical stability and microbial challenge hold time of nonpreserved telavancin for injection was determined using common reconstitution diluents and intravenous (IV) infusion solutions stored at room temperature with light (ambient) or at 2°C to 8°C without light (refrigeration). METHODS Telavancin was reconstituted with 5% dextrose, 0.9% normal saline, or s...