“All models are wrong but some are useful" [1]. We address the problem of identifying which diagnosis models are more useful than others. Models are critical to diagnostics inference, yet little work exists to be able to compare models. We define the role of models in diagnostics inference, propose metrics for models, and apply these metrics to a tank benchmark system. Given the many approaches...

An analysis of the climate parametrization scheme adopted by conventional forest gap models revealed that most models assume a constant climate and are difficult to calibrate consistently. Tree growth showed unrealistically sensitive threshold effects along ecological gradients of temperature and precipitation. A new parametrization was compared with its predecessors in terms of the model's cap...

Title: Oscillometric measure of blood pressure detects association between orthostatic hypotension and depression in population based study of older adults Author's response to reviews: see over Dear Sir/Madam The authors would like to thank the reviewers for their comments and suggestions with regard to the manuscript entitled 'Oscillometric measure of blood pressure detects association betwee...

BACKGROUND Pay for performance (P4P) schemes have become increasingly popular innovations in primary care and have generated questions about their effect on improving quality of care. AIMS To provide a brief outline of the international evidence on the relationship between P4P schemes and quality improvement. METHOD We conducted a literature search using relevant databases and reference lis...

All models are wrong, but some are useful. 2 Acknowledgements The authors of this guide would like to thank David Warde-Farley, Guillaume Alain and Caglar Gulcehre for their valuable feedback. Special thanks to Ethan Schoonover, creator of the Solarized color scheme, 1 whose colors were used for the figures. Feedback Your feedback is welcomed! We did our best to be as precise, informative and u...

Max Weber claimed that while Protestantism provided the proper ethos necessary to spur capitalism, Eastern religions did not. Japan’s economic success has belied his hypothesis, and while there have been various theories explaining its rise, perhaps Weber’s own claims regarding the connection between embeddedness and capitalism best explain Japan’s rise. Simply put, Japanese capitalism was born...

Alman ceza hukukunda intihar etmek suç değildir. Suç olmayan bir eyleme iştirak edenler de hukukundaki bağlılık kuralı gereğince cezalandırılamaz. Ancak kamuoyunda ve bilim çevrelerinde intihara yardım niteliğindeki bazı eylemlerin cezalandırılması gerektiği konusu, yoğun olarak tartışılmaktadır. Bu tartışmalar neticesinde 2015 yılında, belli eylemler Ceza Kanunu’nun 217. paragrafı ile cezai ya...

Both the Human papillomavirus (HPV) major (L1) and minor (L2) capsid proteins have been well investigated as potential vaccine candidates. The L1 protein first oligomerizes into pentamers, and these capsomers assemble into virus-like particles (VLPs) that are highly immunogenic. Here we examine the potential of using HPV type 16 (HPV-16) L1 subunits to display a well-characterized HPV-16 L2 epi...