An UPLC method has been developed and subsequently validated for the determination of antimigraine drug and its process-related impurities. Separation was achieved with Halo C18, 50x 4.6 mm, 2.7μm column and 1.36 g ofmonobasic potassium phosphate in 1000 mL of water with 2 mL of triethylamine at pH 6.8 using H3PO4, acetonitrile and methanol in the ratio of 55 : 38 : 7 as eluent in isocratic mod...

x86-64 is a 64-bit extension for the IA32 architecture, which is supported by the next generation of AMD CPUs. New features include 64-bit pointers, a 48-bit address space, 16 general purpose 64-bit integer registers, 16 SSE (Streaming SIMD Extensions) registers, and a compatibility mode to support old binaries. The Linux kernel port to x86-64 is based on the existing IA32 port with some extens...

Efficient, reliable trapping of execution in a program at the desired location is a hot area of research for security professionals. The progression of debuggers and malware is akin to a game of cat and mouse each are constantly in a state of trying to thwart one another. At the core of most efficient debuggers today is a combination of virtual machines and traditional binary modification break...

Microprocessors continue on the relentless path to provide more performance. Every new innovation in computing—distributed computing on the Internet, data mining, Java programming, and multimedia data streams—requires more cycles and computing power. Even traditional applications such as databases and numerically intensive codes present increasing problem sizes that drive demand for higher perf...

The IA-64 architecture, co-developed by HP and Intel, is going to reach market some time next year with Merced as its first implementation. Major industry players have endorsed this new architecture and technical details are gradually becoming publicly available. However, the complete architecture will not be fully disclosed until machines become available. To provide for early availability of ...

This paper examines one of the core technologies in colour printing solutions colour image information processing and discusses our related development activities in the fields of colour science research, colour processing research and development, and colour printer product technology. The first topic, colour science research 1) 2) 3) 4) 5), forms a background for both colour processing resear...