Antibody-directed enzyme prodrug therapy (ADEPT) using anti-TAG-72 antibody and geldanamycin (GA) prodrug were validated in vitro. To understand the complexity and to explore optimal therapeutic regimens for ADEPT in vivo, a physiologically based pharmacokinetic model (PBPK) is applied to analyze each anatomical component/organ. The baseline model predicts that active drug tumor/plasma exposure...

A high power electronic chip was simulated experimentally to investigate upper cooling capabilities using a variety of pool boiling enhancement techniques. Parametric effects of system pressure, subcooling, surface augmentation, and choice of coolant on boiling heat transfer from a vertical 12.7'x 12.7 mm flat surface were examined. The two fluorocarbon coolants tested, FC-72 and FC-87, resulte...

backgrounds and aims: p53 gene is regarded important in pathogenesis of different cancers. therefore, this study aimed to investigate the frequency of p53 gene codon 72 arg/pro polymorphism in women suffering from breast cancer. materials and methods: a total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. genomic dna was extracted...

the tp53 gene is one of the most frequently mutated genes amongst human malignancies, particularly tp53 codon 72 polymorphism. furthermore, an association between the tp53 codon 72 variants and prostate cancer has been reported in several studies. although some studies have indicated an association between the tp53 arg/arg variant and an increased risk for prostate cancer, other studies have sh...

Given a polarization of an even unimodular lattice and integer k ≥ 1, we define a family of unimodular lattices L(M, N, k). Of special interest are certain L(M,N, 3) of rank 72. Their minimum norms lie in {4, 6, 8}. Norms 4 and 6 do occur. Consequently, 6 becomes the highest known minimum norm for rank 72 even unimodular lattices. We discuss how norm 8 might occur for such a L(M,N, 3). We note ...

1 Instituto de Farmácia e Nutrição, Lab. Genética, UNIFENAS, 37130-000, Alfenas, MG, Brazil 2 Universidade do Oeste de Santa Catarina, Campus de Videira, SC, Brazil 3 Laboratório de Farmacognosia, Departamento de Ciências Farmacêuticas, USP, Ribeirão Preto, SP, Brazil 4 Universidade de Estadual Paulista-UNESP, Faculdade de Filosofia e Ciências, Departamento de Fonoaudiologia, Marlia, SP, Brazil...

By computer search we show that the lattice Γ from [9] is the unique extremal even unimodular 72-dimensional lattices that can be constructed as proposed in [6].

1. A procedure for the rapid, accurate estimation of haptoglobin in serum and purified preparations is described, based on the peroxidase activity of haemoglobin in its complexes with haptoglobin. 2. Hydrogen peroxide, guaiacol and methaemoglobin reagents are used, under well-defined conditions which reduce the peroxidase activity of free haemoglobin essentially to zero. The reaction is followe...