The incidence of tuberculosis (TB) and its risk factors in China remains unclear. This study examined TB incidence and relative risk factors in rural areas of China. Participants (n = 177,529) were recruited in Xiangtan County (in the central area of China) and in Danyang County (in the eastern area of China) in 2009 and a followed-up study was conducted for one year. The incidence density of p...

Background: Recent linkage between primary and secondary care data has provided valuable information for studying heath outcomes that may initially present in different health care settings. The aim of this study was therefore, twofold: to use linked primary and secondary care data to determine an optimum definition for estimating the incidence of first VTE in and around pregnancy; and secondly...

BACKGROUND Anal cancer rates are higher for human immunodeficiency virus (HIV)-infected adults than for uninfected adults. Limited published data exist characterizing the incidence of precursor lesions detected by anal cytology. METHODS The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy was a prospective cohort of 700 HIV-infected participants in 4 US citi...

We examined racial differences in gout incidence among black and white participants in a longitudinal, population-based cohort and tested whether racial differences were explained by higher levels of serum urate. The Atherosclerosis Risk in Communities Study is a prospective, US population-based cohort study of middle-aged adults enrolled between 1987 and 1989 with ongoing annual follow-up thro...

It is with great sadness we pay tribute to M. Thomas Inge who recently died aged 85. The contribution Tom, as he was always known by in person, made research popular culture and comics schola...

CONTEXT High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI). OBJECTIVE To assess whether genetic data are consistent with this association being causal. DESIGN, SETTING, AND PARTICIPANTS Three studies of white individuals from Copenhagen, Denmark, were used: the Copenhagen City Heart Study (CCHS), a prospective general population study with 16 year...

BACKGROUND Skin and soft tissue infections (SSTIs) are common in the era of community-associated methicillin resistant Staphylococcus aureus among HIV-infected patients. Recurrent infections are frequent. Risk factors for recurrence after an initial SSTI have not been well-studied. METHODS Retrospective cohort study, single center, 2005-2009. Paper and electronic medical records were reviewed...

AIMS Adherence to evidence-based treatments and its consequences after acute myocardial infarction (MI) are poorly defined. We examined the extent to which clopidogrel treatment initiated in hospital is continued in primary care; the factors predictive of clopidogrel discontinuation and the hazard of death or recurrent MI. METHODS AND RESULTS We linked the Myocardial Ischaemia National Audit ...

Background Parkinson disease is the second most common neurodegenerative disease and the proportion of people suffering from parkinsonism and Parkinson disease is expected to increase as populations age. Few studies investigated the incidence of parkinsonism and Parkinson disease in the general population, and most of these were based on clinical data only. Objective To estimate the incidence o...