Tocopherols are a class of four natural compounds that can provide nutrition and function as antioxidant in both plants and animals. Maize kernels have low α-tocopherol content, the compound with the highest vitamin E activity, thus, raising the risk of vitamin E deficiency in human populations relying on maize as their primary vitamin E source. In this study, two insertion/deletions (InDels) w...

Antioxidants have a number of potential health benefits. The present investigation was designed to determine the relationship between serum alpha- and gamma-tocopherol levels (powerful antioxidants), and leukocyte telomere length (a biomarker of biological aging). A cross-sectional design was employed to study 5768 adults from the National Health and Nutrition Examination Survey (NHANES). DNA w...

A randomized, double-masked, crossover clinical trial was carried out to evaluate whether lovastatin therapy (60 mg daily) affects the initiation of oxidation of low density lipoprotein (LDL) in cardiac patients on alpha-tocopherol supplementation therapy (450 IU daily). Twenty-eight men with verified coronary heart disease and hypercholesterolemia received alpha-tocopherol with lovastatin or w...

The aim of this study was to determine the effects of vitamin E (alpha-tocopherol) on the low density lipoprotein (LDL) receptor, a cell surface protein which plays an important role in controlling blood cholesterol. Human HepG2 hepatoma cells were incubated for 24 hours with increasing amounts of alpha, delta, or gamma-tocopherol. The LDL receptor binding activity, protein and mRNA, 3-hydroxy-...

Modern hip and knee endoprosthesis are produced in titanium and to reduce the friction at the contact area polymer parts, mainly ultra-high molecular weight polyethylene (UHMW-PE), are installed. The polyethylene is impregnated with αtocopherol (vitamin E) before processing for remarkable decrease of oxidative degradation. Cross linked UHMW-PE offers much higher stability, but α-tocopherol cann...

α-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. α-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study the roles of α-tocopherol in the cerebellum, we used the α-tocopherol transfer protein for the murine version (Ttpa(-/)(-)) mice which lack the α-to...

A relatively simple spectrophotometeric method has been developed for the determination of alpha tocopherol in human plasma. Method is modification of a previous micromethod base on oxidation of alpha tocopherol by ferric chloride. The complex of ferrous ions (generated in this reaction) with bathophenanthroline is determined spectrophotometrically at 536 nm. The absorbance of this colored comp...

The incidence of prostate cancer is increasing and there is continuing research into possible preventive treatments. Vitamin E, an antioxidant, has been studied as a chemoprotective agent in recent literature with α-Tocopherol being the most prominently studied. Although α-Tocopherol is found in highest concentration in the body, there are seven other isomers of vitamin E as tocopherols and toc...

Background: Little is known about factors that modulate dietary -tocopherol bioavailability. Objectives: The study aimed to assess the efficacy of vitamin E–fortified apples as a low-fat vitamin E delivery system, the influence of fat on vitamin E absorption, and human vitamin E requirements by using plasma -tocopherol kinetics at a dosage of -tocopherol

Designing enriched probiotic supplements may have some advantages including protection of probiotic microorganism from oxidative destruction, improving enzyme activity of the gastrointestinal tract and probably increasing half-life of micronutrient. In this study Saccharomyces cerevisiae enriched with α-tocopherol produced as an accumulator and transporter of a lipid soluble vitamin for the fir...