OBJECTIVE Erythropoiesis stimulating agent (ESA) administration may reduce mortality in severe traumatic brain injury (sTBI). SUMMARY BACKGROUND DATA It has been established that the administration of ESA in critically ill trauma victims has been associated with improved outcomes. Recent experimental and clinical data showed neuroprotective effects of ESA, however, the literature regarding im...

HYPOTHESIS Survival until a fixed time after injury is a more useful outcome variable than survival until hospital discharge. DESIGN We sought to determine whether 30-day survival could be accurately predicted by hospital discharge status. SETTING Academic research. PATIENTS We analyzed Medicare fee-for-service records for patients 65 years or older admitted with a principal diagnosis of ...

Purpose: Pelvis fractures are associated with bladder and urethral injury (BUI). The purpose of this study was to identify risk factors BUI in patients pelvic fracture.Methods: Patients (> 18 years) (<i>N</i> = 314) at our hospital between January 2015 June 2020 were retrospectively analyzed for age, sex, cause injury, initial vital signs, urine red blood cell (RBC) count, Glasgo...

BACKGROUND The aim of this study was to assess validation evidence for a sedation scale for dogs. We hypothesized that the chosen sedation scale would be unreliable when used by different raters and show poor discrimination between sedation protocols. A sedation scale (range 0-21) was used to score 62 dogs scheduled to receive sedation at two veterinary clinics in a prospective trial. Scores re...

OBJECTIVES To determine the relationship between emergent intubation (emergency department and field intubation cases combined) and mortality in patients with traumatic brain injury while controlling for injury severity. METHODS Retrospective observational study of 981 (35.2% intubated, 64.8% not intubated) patients with TBI evaluating the association between intubation status and mortality. ...

OBJECTIVE Determine the effects of BMI on the risk of serious-to-fatal injury (Abbreviated Injury Scale ≥ 3 or AIS 3+) to different body regions for adults in frontal, nearside, farside, and rollover crashes. DESIGN AND METHODS Multivariate logistic regression analysis was applied to a probability sample of adult occupants involved in crashes generated by combining the National Automotive Sam...

Hypoxia-inducible factor 1α (HIF-1α) is an important transcription factor in mediating oxygen homeostasis that can regulate vascular endothelial growth factor (VEGF) gene transcription. HIF-1α can induce neovascularization in ischemic injury. This research observed HIF-1α and VEGF expression in traumatic lung injury (TLI) to discuss their correlation. Healthy male SD rats at 7-week old were ran...