Objective(s): To investigate and compare quantitative accuracy of kidney absorbed dose measures made from both 2D and 3D imaging in patients receiving 177LuDOTATATE (Lutate) for treatment of neuroendocrine tumours (NETs). Methods: Patients receiving Lutate therapy underwent both whole body planar imaging and SPECT/CT imaging over the kidneys at time points 0.5, 4, 24, and 96-120 hours after inj...

A study was made on the loss of the reproductive capacity of HeLa S3 cells irradiated in vitro under both oxygenated and anoxic conditions with D-T neutrons (14 Mev) at 1, 20, 30, 150 and 400 rads/minute at 25•Ž and 37•Ž and with 180 kvp X-rays at 100 rads/minute at 37•Ž. 1) RBE of neutrons measured at a range of 2 to 10% survival was 2.67-2.62 under oxygenated conditions and 3.83.4.61 under an...

The change in frequencies of D. melanogaster and D. simulans in competition experiments was used to measure the effect of radiation on the fitness of a population. A dose of 250 or 500 rads given to the males of highly inbred lines of D. simulans at the beginning of competition and every three weeks thereafter increased the relative frequency of the irradiated population. If the dose was increa...

The paper presents an innovative approach towards development of real time dosimetry using a chemical dosimeter for measurement of absorbed radiation dose in the range between 1 and 400 Gy. Saturated chloroform solution in water, a well known chemical dosimeter, is used to demonstrate the concept of online measurement of radiation dose. The measurement approach involves online monitoring of inc...

Introduction: The aim of this study was to evaluate the human organ absorbed dose of [111In]In-DTPA-antiMUC1, as a newly developed radioimmunoconjugate. Methods: [111In]In-DTPA-antiMUC1 was prepared at optimized conditions while the radiochemical purity of the tracer was investigated using ITLC method. Biodistribution of the radiolab...

Background. Success of radiotherapy relies on accurate dose delivery. In vivo dosimetry improves control of treatment quality. Patients and methods. In vivo dosimetry with commercial diodes was performed in 209 rectal cancer patients treated with four-field box technique. The diodes measured either entrance or exit dose in each treatment field. The results were compared to the planned values an...

− In the current brachytherapy practice, the procedures to determine the absorbed dose imparted to the patient are affected by an uncertainty higher than in radiotherapy with external beams. That could reduce the success of brachytherapy treatments. Most of the uncertainty is due to a lacking metrology: no absorbed-dose primary standards are so far available to assure direct traceability in dos...