We studied the developmental sequence of transmitter synthesis and neurotransmission by parasympathetic neurons in rat heart. Measurements of atrial and ventricular choline acetyltransferase activity were used as indicators of acetylcholine synthesis, and negative chronotropic effects of neuronal stimulation were used to demonstrate neuroeffector transmission. Activity of the mitochondria! enzy...

CREB-binding proteins (CBP) and p300 are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, including CREB, nuclear receptors, and STATs. CBP and p300 function in part by mediating the assembly of multiprotein complexes that contain additional cofactors such as p300/CBP interacting protein (p/CIP), a member of the p160/SRC family of coactiv...

Mammalian circadian rhythms are controlled by a master pacemaker located in the suprachiasmatic nuclei (SCN), which is synchronized to the environment by photic and nonphotic stimuli. One of the main functions of the SCN is to regulate peripheral oscillators to set temporal variations in the homeostatic control of physiology and metabolism. In this sense, the SCN coordinate the activity/rest an...

In this paper we define and analyze notions of detectability in stochastic discrete event systems (SDES). More specifically, we introduce the notions of A-detectability and AA-detectability which focus on characterizing our ability to estimate the true current state of a given SDES with increasing certainty as we observe more output symbols. We discuss observer-based techniques that can be used...

Histone acetyltransferase 1 is the founding member of the histone acetyltransferase superfamily and catalyzes lysine acetylation of newly synthesized histone H4. Here we report a 1.9-Å resolution crystal structure of human histone acetyltransferase 1 in complex with acetyl coenzyme A and histone H4 peptide. The crystal structure reveals that the cofactor and the side chain of lysine 12 of histo...

In this paper, we summarise studies which have been carried out on the metabolism of nucleic acids (maternal RNA, DNA, nucleolytic enzymes) in avian oocytes and embryos (Japanese quail, Coturnix coturnix japonica ) within the last 10 years in the Institute of Genetics and Animal Breeding of the Polish Academy of Sciences. The accumulation of maternal RNA in the quail oocyte during oogenesis is ...