Submit Manuscript | http://medcraveonline.com Abbreviations: CSCs: Cancer Stem-Like Cells; EGFR: Epidermal Growth Factor Receptor; GBM: Glioblastoma Multiforme; JAK: Janus Tyrosine Kinase; MTOR: Mechanistic Target of Rapamycin; MAPK: Mitogen-Activated Protein Kinase; NF1: Neurofibromin-1; NF-κB: Nuclear Factor-Kappa B; PI3K: Phosphoinositide-3Kinase; PDGFRA: Platelet Derived Growth Factor Recep...

OBJECTIVE Thrombin is generated in significant quantities during cardiopulmonary bypass and mediates adverse events, such as platelet aggregation and proinflammatory responses, through activation of the high-affinity thrombin receptor protease-activated receptor 1, which is expressed on platelets and endothelium. Thus antagonism of protease-activated receptor 1 might have broad therapeutic sign...

In previous studies, two forms (alpha and beta) of the oestrogen receptor, with different immunological characteristics, were observed in the cytosol fraction of fetal guinea-pig uterus, by using a monoclonal antibody to the human oestrogen receptor (D547Sp gamma). Only the alpha form was recognized by the antibody, shifting its sedimentation coefficient in high-salt sucrose gradients. The pres...

Liver cirrhosis is characterized by hepatic dysfunction with extensive accumulation of fibrous tissue in the liver. In response to chronic hepatic injury, hepatic portal myofibroblasts and activated hepatic stellate cells (HSCs) play a role in liver fibrosis. Although administration or gene expression of hepatocyte growth factor (HGF) leads to improvement in hepatic fibrosis/cirrhosis, the rela...