Investigations are presented in the light of band anticrossing theory (ВАС) influence on emission spectra structural features self-activated zinc selenide and crystals with activators. The disunity numerous literature data makes it difficult to understand this question. Theory-ВAС requires taking into account isoelectronic admixture oxygen, which is invariably present ZnSе lattice, zone structu...

Economic growth and rapid urbanization have resulted in the increase demand for infrastructure development. To meet this ever increasing demand, conventional construction materials such as concrete are used, which requires an energy intensive process that turn impacts environment adversely. Ordinary Portland Cement, being dominant binder industry, contributes around 8% of worldwide annual carbo...

The enzyme sirtuin 1 (SIRT1) is a major target for the treatment of various metabolic disorders. Herein, a practical synthesis of imidazo[1,2-b]thiazole derivatives, one of the most comprehensively studied class of synthetic SIRT1 activators, is presented. The synthesized SIRT1 activators, the in vitro-identified metabolite of SRT1720, and the eightfold deuterated analytical standards were obta...

polyphenol oxidase (ppo) activity varied in differentiation from hyphae to rhizomorph and croute in a. mellea. in undifferentiated hyphae there was not any ppo activity, while croute showed the highest activity. electrophoresis in the presence of sds allows the detection of intensive enzyme forms of ppo, and can also convert slower migrating enzyme forms to faster ones. some fluorescent compoun...

Three prothrombin activators; ecarin, which was originally isolated from the venom of the saw-scaled viper Echis carinatus, trocarin from the rough-scaled snake Tropidechis carinatus, and oscutarin from the Taipan snake Oxyuranus scutellatus, were expressed in mammalian cells with the purpose to obtain recombinant prothrombin activators that could be used to convert prothrombin to thrombin. We ...

Transcriptional regulatory mechanisms are fundamentally similar in eukaryotic organisms [1,2]. Components of the RNA polymerase II (Pol II) machinery are highly conserved and, in some cases, functionally interchangeable. Transcriptional activators with similar DNA-binding specificities are present from yeast to human, and acidic activation domains stimulate transcription across a wide range of ...

Type 2 diabetes is characterized by elevated blood glucose levels resulting from a pancreatic b-cell secretory insufficiency combined with insulin resistance, most significantly manifested in skeletal muscle and liver (1). If untreated, diabetic complications develop that cause loss of vision, peripheral neuropathy, impaired kidney function, heart disease, and stroke. The disease has a polygeni...

BACKGROUND Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. The aim of this study is to evaluate the anti-inflammatory effects of Nrf2 activators on human renal mesangial cells (HRMCs) and the development of lupus nephritis (LN) in mice. METHODS To assess Nrf2 activation in vitr...

NF-E2 related factor-2 (Nrf2) promotes the transcription of many cytoprotective genes and is a major drug target for prevention of cancer and other diseases. Indeed, the cancer-preventive activities of several well-known chemical agents were shown to depend on Nrf2 activation. It is well known that chemopreventive Nrf2 activators stabilize Nrf2 by blocking its ubiquitination, but previous studi...

Efforts to increase the potency of transcriptional activators are generally unsuccessful because poor expression of activators in mammalian cells limits their delivery to target promoters. Here we report that the effectiveness of chimeric activators can be dramatically improved by expressing them as noncovalent tetrameric bundles. Bundled activation domains are much more effective at activating...