Target search by active agents in rugged energy landscapes has remained a challenge because standard enhanced sampling methods do not apply to irreversible dynamics. We overcome this nonequilibrium rare-event problem developing an algorithm generalizing transition-path Brownian This method is exemplified and benchmarked for paradigmatic two-dimensional potential with high barrier. find that eve...

benzofuran as an important heterocyclic compound is extensively found in natural products as well as synthetic materials. since benzofuran drivatives display a diverse array of pharmacological activities, an interest in developing new biologically active agents from benzofuran is still under consideration. this review highlights recent findings on biological activities of benzofuran derivatives...