Our research addresses constructing a dynamic normal profile for anomaly detection systems without requiring timeconsuming retraining. We propose to continuously update normal profiles by keeping the most recently employed patterns whose amount is dynamically determined. Active window adjustment through a simplified concept drift algorithm helps to keep relevant instances without having to cont...

In this paper, we demonstrate a technique called active probing used to study TCP implementations. Active probing treats a TCP implementation as a black box, and uses a set of procedures to probe the black box. By studying the way TCP responds to the probes, one can deduce several characteristics of the implementation. The technique is particularly useful if TCP source code is unavailable. To d...

design of selective cyclooxygenase-2 (cox-2) inhibitors is still a challenging task because of active site similarities between cox isoenzymes. to help with this issue, we tried to generate a 3d-qsar (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of cox-2 active sites. compounds in a series of resveratrol derivatives inhibitors with ...

Phenytoin has been an effective anticonvulsant agent for over 60 years, although its clinical use is complicated by nonlinear pharmacokinetics, a narrow therapeutic index, and metabolically based drug-drug interactions. Although it is well established that CYP2C9 is the major cytochrome P450 enzyme controlling metabolic elimination of phenytoin through its oxidative conversion to (S)-5-(4-hydro...

We have measured the processivity of telomeric DNA extension by Euplotes aediculatus telomerase at various concentrations of the nucleotide substrates dGTP and dTTP. The maximum processivity (approximately 3 repeats) was observed at approximately 100 microM of each dNTP. Processivity decreased as the dNTP concentrations were reduced and, surprisingly, as the concentration of dGTP was increased....