Background: To attain whether the effects of low and high doses of estrogen, progesterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (COX-1) activity. Materials and Methods: Acute and chronic administration of estrogen (1 and 5 mg/ kg), ...

conclusions: the potent effect of corticosteroids in the rapid improvement of respiratory compromise associated with thyroid lymphoma represents an important clinical finding. this opens the possibility for the favorable response to corticosteroid therapy to be regarded as a possible preliminary diagnostic tool for thyroid lymphoma in acute respiratory distress patients in the absence of trache...

We evaluated the potency of truncated secretory leukoprotease inhibitor (truncated SLPI) in a human sputum elastase (HSE)-induced lung injury model and in a specific neutrophil-mediated acute lung injury model in hamsters. Intratracheal administration of HSE induced acute lung hemorrhage that could be measured by determination of the hemoglobin content in the bronchoalveolar lavage fluid. Intra...

drug induced acute kidney injury (aki) has been implicated in 8% to 60% of all cases of in-hospital aki and as such is a recognized source of significant morbidity and mortality. evaluation of incidence, risk factors, onset time, and outcome of  antibiotics' associated acute kidney injury. during one-year period, all patients who developed acute kidney injury during their hospital stay in the i...

A 54-year-old woman presented to hospital after deliberate acute ingestion of paracetamol 20 g. Despite early administration of a standardised acetylcysteine regimen, the patient developed acute liver impairment and acute renal impairment. Prolonged acetylcysteine administration and supportive measures allowed restoration of normal liver and renal function. Early presentation to hospital and pr...