Clinical Studies on Primary Glomerular Disease The purpose of this study can be divided into two main categories: I) recent study of the mechanism of development of primary glomerular disease and II) recent problems in the treatment of advanced glomerular disease. I. The morbid types and development of primary glomerular disease Classification of primary glomerular disease has been studied by m...

Recent reports emphasise the importance of examining the morphological features of erythrocytes in urine as an aid to determining their origin (glomerular or non-glomerular).'3 Finding pronounced distortion of the majority of the erythrocytes favours a glomerular origin and might be especially helpful for diagnosing glomerulonephritis in patients presenting without erythrocyte casts or proteinu...

While antineutrophil cytoplasmic antibody (ANCA) positivity has been documented in some patients with postinfectious glomerulonephritis (PIGN) and is associated with more severe disease, antiphospholipid antibodies (APA) are not known to be a common occurrence. We describe a child with severe acute kidney injury who was noted to have prolonged positivity of both ANCA and APA; a renal biopsy sho...

Mixed cryoglobulinemia (MC), the most common extrahepatic manifestation of HCV, may lead to renal involvement ranging from mild urinary abnormalities to nephritic syndrome, eventually evolving to renal failure requiring renal replacement therapy. HCV eradication with pegylated interferon (PEG-IFN) and ribavirin (RBV) is the only curative treatment for MC-related membranoproliferative glomerulon...

The possible role of immunologic mechanisms in acute poststreptococcal glomerulonephritis was suggested in 1908 by Schick (2), who compared the delay in appearance of serum sickness after injection of heterologous serum to the latent period between scarlet fever and onset of acute glomerulonephritis. Evidence in support of this concept is the depression of serum complement during the early stag...

A 70-year-old man complained of muscle pain in his neck, shoulders and pelvic girdle. Proteinuria and hematuria subsequently developed. Blood analysis showed increased acute phase reactants. The histology of renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. There were no signs of autoimmune diseases, malignancies and bacterial or viral infections. His extrarenal sympto...

reported. In contrast, we recently reported a case of WGin whomthe first clinical manifestation was acute renal failure due to periglomerular granulomatosis with crescentic glomerulonephritis and the late development of respiratory lesion. The case could be a "delayed variant" or limited form of WG localized in the kidney (1). Accordingly, the combination of organ involvement is not sufficient ...

Rapidly Progressive Glomerulonephritis are a group of renal diseases which are still posing serious threat to human health and survival. They are all characterised by acute and rapid deterioration of renal function. Renal biopsy reveals extracapillary glomerulonephritis, most frequently circumferential and diffuse, and immunofluorescence findings continue to represent the most important clue to...