Differentiation syndrome (DS) represents a life acute promyelocytic leukemia (APL) undergoing induction therapy with all (ATRA) or arsenic trioxide (ATO). It affected about 20 definitive diagnostic criteria. Clinically, DS is characterized by weight gain, fever not attributable to infection, respiratory distress, cardiac involvement, hypotension, and/or acute renal failure. At the histological ...

Daunorubicin induces complete remissions during the first 5 days (25#{176}/o) or due to in about 500/0 of patients with acute prosepsis during the second and third week myelocytic leukemia. The median duration (25#{176}/o). Long-term survivals are more freof these remission is 26 mo. Failures are quent than in the other acute granulocytic mainly due to hemorrhages as a result of leukemias. diss...

BACKGROUND The estimated incidence of acute promyelocytic leukemia (APL) is approximately 6 cases per 10 million people per year with no apparent differences between sexes. The age of APL cases is younger than that of other acute myeloid leukemias (AML). Spatial and temporal clusters of APL have been reported. These observations suggest a possible selective role for environmental and/or occupat...

Cure of acute promyelocytic leukemia (APL) is now a possibility for most patients through the use of state-of-the-art treatments, which include simultaneous administration of all-trans retinoic acid (ATRA) and anthracycline-based chemotherapy for induction and consolidation, as well as ATRA-based maintenance. Risk-adapted strategies to modulate treatment intensity may be an effective approach t...

Acute promyelocytic leukemia (APL) is a unique form of acute myeloblastic leukemia, which manifests by DIVC, massive hemorrhage and hypofibrinogenemia and has a rapidly fatal outcome. Here we report a case of APL in a 38-year-old woman, who presented with an acute episode of severe menorrhagia for the first time and died due to hemorrhagic complications. The diagnosis of hematological disorders...

Acute promyelocytic leukemia (APL) represents a medical emergency with a high rate of early mortality. As a consequence, as soon as the diagnosis is suspected based upon cytologic criteria, it is necessary to start all- trans retinoic acid (ATRA) treatment without delay. For patients with newly diagnosed APL, induction therapy with ATRA plus anthracycline based chemotherapy is recommended. At p...