A 51-year-old male with uncontrolled asthma and recent convalescence from severe acute respiratory syndrome coronavirus-2c pneumonia presented cough, dyspnea, chest pain. Evaluation revealed significant peripheral eosinophilia, elevated troponin, biventricular failure resulting in cardiogenic shock. He was diagnosed eosinophilic myocarditis subsequently started on high-dose steroids. As he also...

ykl-40 (chitinase-3-like-1) has been introduced as a marker of inflammation in asthma. the aim of this study was to determine the role of ykl-40 in asthma and to evaluate the relationship between ykl-40 and asthma severity. in the study, 60 non-smoker asthma patients without additional diseases (aged between 20-60 years, female: 34) were grouped [group i: well controlled asthma patients (n: 30)...

OBJECTIVE To review the efficacy and safety of inhaled corticosteroids (ICSs) when used to reduce daily oral corticosteroid (OCS) requirements in patients with severe persistent asthma and periodic requirements in patients with acute asthma exacerbations. DATA SOURCES Clinical studies of the OCS-sparing effects of ICSs were located by searching MEDLINE databases from 1966 onward using the ter...

  Background and Objectives: Apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. Our purpose was to investigate the degree of expression of the Bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity.    Materials and Methods: The study was carried out in Mostafa Khomeini Ho...

OBJECTIVES To describe the patient demographics, outcomes and trends of admissions with acute severe asthma admitted to adult critical care units in England and Wales. DESIGN 10-year, retrospective analysis of a national audit database. SETTING Secondary care: adult, general critical care units in the UK. PARTICIPANTS 830 808 admissions to adult, general critical care units. PRIMARY AND...