Facially amphiphilic polymers carrying cationic and hydrophobic groups on the same repeat unit have shown promising antimicrobial activity biocompatibility, yet they are prone to suffer from protein adhesion which may induce biofilm formation. To overcome this problem, poly(diitaconate)-based copolymers with cationic/hydrophobic protein-repellent/charge-neutral units synthesized. The bioactivit...

Adhesion of macrophages to material substrates plays an essential role in many biological behaviors and biomedical procedures, including wound healing, cancer treatment biomaterial implantation. Therefore, altering the adhesion using design may help control their function. In this work, we developed a straightforward method render hydrogel surface more hydrophobic demonstrated that on hydrogels...

background: in this study the haemolymph components of infected and none infected lymnaea gedrosiana with xiphidiocercaria larvae was compared. methods: five hundred fifty lymnaea snails were collected from ilam and mazandaran prov­inces, iran, during 2008-2009. the snails were transported to the lab at tehran university of medi­cal sciences and their cercarial sheddings were studied. haemolmyp...

The sea cucumber Holothuria forskåli possesses a specialized system called Cuvierian tubules. During mechanical stimulation white filaments (tubules) are expelled and become sticky upon contact with any object. We isolated a protein with adhesive properties from protein extracts of Cuvierian tubules from H. forskåli. This protein was identified by antibodies against recombinant precollagen D wh...

OBJECTIVE To explore the effect of dexamethasone (DEX) on monocyte adhesion function and its underlying mechanism. METHODS The effects of DEX and fasudil on adhesion of cultured U937 monocytes to human umbilical vein endothelial cells (HUVEC) following stimulation with phorbol myristate acetate (PMA) were studied; Changes in the Rho-associated coiled-coil protein kinase 1 (ROCK1) protein cont...

The effects of cell adhesion on leukemia cell proliferation remain poorly documented and somehow controversial. In this work, we investigated the effect of adhesion to fibronectin on the proliferation of acute myeloid leukemia (AML) cell lines (U937 and KG1a) and CD34+ normal or leukemic primary cells. We observed an increased rate of proliferation of AML cells when adhered to fibronectin, conc...

Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity resist protein, bacterial, and cell adhesion typically applied polymeric systems. Here, the self-assembly of strongly interacting small molecule amphiphiles is reported produce nanoribbons for applications. Synthesized spontaneously form micrometers-long with nanometer-scale cross-sections intrinsica...

The regulation of adhesion and the subsequent behavior fibroblast cells on surface biomaterials is important for successful tissue regeneration wound healing by implanted biomaterials. We have synthesized poly(ω-methoxyalkyl acrylate)s (PMCxAs; x indicates number methylene carbons between ester ethyl oxygen), with a carbon chain length = 2–6, to investigate cell including adhesion, proliferatio...

Regulated adhesion enables T cells to migrate through tissue and transiently interact with an endless succession of cells. Monoclonal antibody (mAb) engagement of the CD3/T cell receptor (TCR) complex results in a rapid and transient augmentation of the adhesion function of LFA-1 and VLA integrin molecules on human T cells. We show in this study that mAb crosslinking of the T cell-specific acce...

The regulation of N-cadherin-mediated intercellular adhesion strength in fibroblasts is poorly characterized; this is due, in part, to a lack of available quantitative models. We used a recombinant N-cadherin chimeric protein and a Rat 2 fibroblast, donor-acceptor cell model, to study the importance of cortical actin filaments and cortactin in the strengthening of N-cadherin adhesions. In wash-...