Aspartic acid is prepared chemically or by the fermentation of carbohydrates. Currently, low molecular weight polyaspartic acids are prepared commercially by heating aspartic acid at high temperatures (>220 C) for several hours in the solid state. In an effort to develop a more rapid, continuous, melt polymerization scheme, aspartic acid was copolymerized with adipic, azelaic, sebacic, and dode...

Salicylic acid (SA) based biodegradable polyanhydrides (PAHs) are of great interest for drug delivery in a variety of diseases and disorders owing to the multi-utility of SA. There is a need for the design of SA-based PAHs for tunable drug release, optimized for the treatment of different diseases. In this study, we devised a simple strategy for tuning the release properties and erosion kinetic...

Adult Refsum disease (ARD) is associated with defective alpha-oxidation of phytanic acid (PA). omega-Oxidation of PA to 3-methyl-adipic acid (3-MAA) occurs although its clinical significance is unclear. In a 40 day study of a new ARD patient, where the plasma half-life of PA was 22.4 days, omega-oxidation accounted for 30% initially and later all PA excretion. Plasma and adipose tissue PA and 3...

The synthesis of adipic acid, which is formed by the reaction cyclohexene oxidized hydrogen peroxide (H2O2), hazardous because highly exothermic nature this and H2O2 decomposition. objective comprehensive study was to investigate illustrate effects sulfuric acid (H2SO4) stabilizer (EDTA) on thermal hazard decomposition green also provided a reference reduce risk reactions. Various calorimetry t...