Farrell recently published an interesting review paper on imaging human brain responses during heating and cooling. Here, he discussed our work on imaging such responses during menopausal hot flashes (HFs). Hot flashes are triggered by small elevations in core body temperature acting within a greatly reduced interthreshold zone in symptomatic menopausal women. This reduction is due to estrogen ...

Zilpaterol hydrochloride is a β-adrenergic agonist, which belongs to a group of compounds known as catecholamines. β-Adrenergic agonists activate β-receptors in muscle and fat causing increased lipolysis, decreased lipogenesis or increased protein accretion (Mersmann, 1998), or both. β-Adrenergic agonists vary greatly in their effect on meat animals. Supplementation of diets with β-agonists can...

alpha-Adrenergic receptor-related properties, specifically, norepinephrine affinity, occupancy and reserve during contraction, were determined in segments of rat resistance arteries. These were obtained from the superior mesenteric bed of spontaneously hypertensive rats and Wistar-Kyoto strain controls. Receptor affinity for norepinephrine in the spontaneously hypertensive rats was significantl...

Propranolol is a nonselective beta-adrenergic receptor blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor agonist agents for available receptor sites. When access to beta-receptor sites is blocked by propranolol, the chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportion...

Adrenergic receptor dysregulation has been described as occurring in both major depressive disorder (MDD) and panic disorder. Measurements of platelet alpha 2 adrenergic receptors in these patients may be confounded by the coexistence or comorbidity of both diagnoses in the same patient. To explore this possibility, we measured platelet alpha 2 adrenergic receptors (3H-clonidine and 3H-yohimbin...

We tested the hypothesis that the human 1-adrenergic receptor displays constitutive activity and that -adrenergic antagonists differ in their ability to modulate this constitutive activity. Transfection of the cDNAs of the human 1and 2-adrenergic receptors into COS-7 cells caused increases in basal cAMP that were proportional to the receptor levels, thus demonstrating constitutive activity for ...

a-Adrenergic receptor-related properties, specifically, norepinephrine affinity, occupancy and reserve during contraction, were determined in segments of rat resistance arteries. These were obtained from the superior mesenteric bed of spontaneously hypertensive rats and Wistar-Kyoto strain controls. Receptor affinity for norepinephrine in the spontaneously hypertensive rats was significantly gr...

Existing data in the literature indicate that alpha 2-adrenergic receptor agonists have a profound hypotensive action, that sodium attenuates the affinity of alpha 2-adrenergic receptors for agonists, that the location of these receptors in the central nervous system is mainly at the sites of cardiovascular regulation, and that these sites exert a constant tonic inhibition of sympathetic vasoco...

Regulation of alpha1-adrenergic receptors (alpha1ARs) is a rapidly expanding field of study due to the involvement of these receptors in several human diseases. For example, upregulation of alpha1bAR mRNA/protein with agonist exposure has been implicated in myocardial hypertrophy. In order to understand mechanisms underlying these findings, initial studies of human alpha1bAR transcription have ...

J Thorac Cardiovasc Surg Yasufumi Kaneda and Hikaru Matsuda Youichi Kawahira, Yoshiki Sawa, Motonobu Nishimura, Satoru Sakakida, Hideki Ueda, BETA-ADRENERGIC AGONIST NORMAL RAT HEART ENHANCES CARDIAC RESPONSE TO GENE TRANSFECTION OF BETA 2–ADRENERGIC RECEPTOR INTO THE http://jtcs.ctsnetjournals.org/cgi/content/full/118/3/446 the World Wide Web at: The online version of this article, along with ...