Clonidine is reported to inhibit the az-adrenoceptor mediated pinnal reflex in mice (3). Clonidine produces its effect by acting as an oc2-adrenergic autoreceptor agonist (1). As such, clonidine is also agonist for presynaptic histamine Hz-receptors (8). To test whether the clonidine-induced inhibition of the pinnal reflex is mediated through adrenergic and/or histaminergic system, the interact...

OBJECTIVE In this paper, effect of the Tolazoline as antagonist of the alpha-2 adrenergic receptors in patients with bronchial asthma and chronic obstructive bronchitis was studied, and also the effect of stimulation with Hexoprenaline of beta-2 adrenergic receptor after bronchi-constriction caused with Propranolol, and Acetylcholine. METHODS Lung function parameters are determined with Body ...

The α1-adrenergic receptors are targets for a number of cardiovascular and central nervous system conditions, but the current drugs for these receptors lack specificity to be of optimal clinical value. Allosteric modulators offer an alternative mechanism of action to traditional α1-adrenergic ligands, yet there is little information describing this drug class at the α1-adrenergic receptors. We ...

Introduction opioid and adrenergic antinociceptive systems are the components of neuroregulatory system of a brain stem. The impact on neuroregulatory systems is a point of theoretical and practical interest for neuroanesthesia. We successfully apply the method of anesthesia, which includes combined impact on opioid (fentanyl) and adrenergic (clonidine) antinociceptive systems. This method of a...

Albumin excretion marks early glomerular injury in hypertension. This study investigated heritability of albumin excretion in twin pairs and its genetic determination by adrenergic pathway polymorphism. Genetic associations used single nucleotide polymorphisms at adrenergic pathway loci spanning catecholamine biosynthesis, storage, catabolism, receptor action, and postreceptor signal transducti...

In Vitro Demonstration of Adrenergic Receptors Controlling Melanophore Responses of the Lizard, Anoli8 carolinensis. JOELM. GOLDMAN AND MAC E. HADLEY 1 The Influence of the Sympathetic Nervous System on the Action of Drugs on the Lens. MARTA WEINSTOCK AND A. S. MARSHALL 8 The Density of Adrenergic Innervation of the Cat’s Nictitating Membrane as a Factor Influencing the Sensitivity of the Isola...

We studied the effects of 5- and 6-hydroxydopamine on adrenergic neurotransmission, fluorescence histochemistry, and nerve terminal ultrastructure in the canine pulmonary vascular bed. Fluorescence histochemistry on stretched preparations and sections of intrapulmonary artery and vein demonstrated that these vessels are well supplied with adrenergic nerves electron microscopy revealed adrenergi...

Previous studies have reported that the numbers of beta- and alpha-adrenergic receptors increase in ischemic myocardium. In vivo studies have raised questions regarding the mechanisms involved in the adrenergic receptor alterations and the consequences of these alterations. The purpose of this study was to evaluate potential relationships among beta-adrenergic receptor changes, high energy phos...

OBJECTIVES Canine atrial cardiomyocytes display a constitutively active, acetylcholine-regulated, time-dependent K+ current (IKH) that contributes to atrial repolarization and atrial tachycardia-induced atrial-fibrillation promotion. Adrenergic stimulation favors atrial arrhythmogenesis but its effects on IKH are poorly understood. METHODS AND RESULTS Adrenergic modulation of IKH was studied ...

Under normal physiological conditions, the heart must be able to increase its output 5-fold to supply the required blood flow to the coronary circulation and skeletal muscles during severe stress. This is normally met by '5-fold increases in myocardial contractility, '3-fold increases in heart rate, and additional increases in stroke volume.1 This increased load requires a commensurate increase...