OBJECTIVE It was the aim of this study to describe a patient with isolated adrenocorticotropic hormone deficiency presenting with a variety of involuntary movements who developed an adrenal crisis due to transient thyroiditis. CLINICAL PRESENTATION AND INTERVENTION A 61-year-old man was hospitalized with a variety of involuntary movements that were suspected manifestations of metabolic enceph...

Previous studies of the relationship between the endogenous opioid system and alcohol consumption have reported contradictory results. To shed light on this connection, we compared plasma concentrations of beta-endorphin, adrenocorticotropic hormone, and cortisol in 70 alcoholic persons after different periods of abstinence and a group of 80 control subjects. Plasma beta-endorphin was decreased...

Two strains of a mammotrophic pituitary tumor were compared; the secretion of adrenocorticotropic hormone had declined appreciably in one and, in the other, was un changed. The secretion of adrenocorticotropic hormone by the pituitary tumor does not appear to be related to the capacity for metastasis inasmuch as metastasis was ob served in the retroperitoneal lymph nodes of animals bearing both...

Cushing's syndrome is a rare disorder resulting from prolonged exposure to excess glucocorticoids. Early diagnosis and treatment of Cushing's syndrome is associated with a decrease in morbidity and mortality. Clinical presentation can be highly variable, and establishing the diagnosis can often be difficult. Surgery (resection of the pituitary or ectopic source of adrenocorticotropic hormone, o...

Adrenal insufficiency is an uncommon cause of hypercalcemia and not easily considered as an etiology of adrenal insufficiency in clinical practice, as not all cases of adrenal insufficiency manifest as hypercalcemia. We report a case of secondary adrenal insufficiency presenting as hypercalcemia and acute kidney injury in a 66-year-old female. The patient was admitted to the emergency departmen...

Intraventricularly administered ACTH,.,, in rats initiated excessive grooming followed by stretching and yawning syndrome. The present study provides evidence that novelty is not an essential prerequisite for its expression and that a variety of environmental variables is not able to influence the peptide-induced behavior. Only very strong motivational variables as severe hunger/thirst and anxi...

BACKGROUND Measurement of basal serum or plasma cortisol concentration is used as a screening test for hypoadrenocorticism in dogs, but is not well characterized. OBJECTIVES To evaluate the sensitivity and specificity of basal serum cortisol to detect hypoadrenocorticism in a population of dogs with a clinical suspicion of hypoadrenocorticism. ANIMALS Four hundred and fifty dogs with nonadr...

Measurable myocurdial infarcts of predictable size and location were produced in dogs by low ligation of the left descending coronary artery just proximal to the origin of the apical branch. Two groups of dogs with such infarct3 were studied, one group being treated intramuscularly with two daily doses of 20 units of Acthar Gel for 9 to 11 days and the other group being untreated. At the end of...

In this chapter, we have reviewed side effects reported for corticotrphins, systemic glucocorticoids, and prostaglandin analogues from January 2020 to June 2021. We used PUBMED, EMBASE International Pharmaceutical Abstracts (IPA) as our search engines. Adrenocorticotropic hormone (ACTH) has found multiple uses but are associated with adverse on cardiac function nervous system. The corticosteroi...

A number of different laboratory procedures investigate the hormonal response in a standardized pharmacological challenge test (dexamethasone-corticotropin releasing hormone; DEX-CRH) or psychosocial stress induction on hypothalamic–pituitary–adrenocortical axis by Trier Social Stress Test (TSST). However, magnitude related to stressors and interaction responsiveness between two tests is still ...