Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode (HMDE) in the potential range from -1.3 to -1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with t...

A stripping method for the determination of hypoxanthine in the presence of copper at the submicromolar concentration levels is described. The method is based on controlled adsorptive accumulation of hypoxanthine-copper at the thin-film mercury electrode followed by a fast linear scan voltammetric measurement of the surface species. Optimum experimental conditions were found to be the use of 1....

ABSTRACT In this paper, the square-wave adsorptive stripping voltammetric (SWAdSV) determination of the veterinary drug closantel using a renewable silver amalgam film electrode (Hg(Ag)FE) is presented. As observed in SWAdSV, closantel provided one well-shaped reduction peak suitable for analytical purposes at potential ca. -1.4 V in the Britton-Robinson (B-R) buffer at pH 7.0. At optimal condi...

Apresentamos um procedimento altamente seletivo e sensível para a determinação simultânea de captopril e de tioguanina baseado em processo de redissolução catódica adsortiva dos complexos de Cu(I)-captopril e de Cu(I)-tioguanina em um eletrodo gotejante de mercúrio. Captopril e tioguanina foram pré-concentrados na superfície da gota do eletrodo de mercúrio usando Cu(II) como sensor e tempo de a...

A differential-pulse polarographic (DPP) method was developed for the determination of brodimoprim (BDP) in Michaelis (MCL) buffer. The peak potential (Ep) occurs at 21.33 V (versus SCE) when the pH of the system is 4.0. The voltammetric behaviour in MCL buffer and the mechanisms of the electrode reaction were studied by, e.g., linear sweep voltammetry, cyclic voltammetry and normal-pulse polar...

Abstract Adsorptive Stripping Voltammetric method for Nimesulide (NIM) determination was developed. As a working electrode, glassy carbon electrode (GCE) modified with black and Nafion (CB-Nafion GCE) used. All measurements were carried out in 0.1 M acetate buffer (pH 4.6). Conducted experiments allowed to optimize differential pulse voltammetry (DPV) instrumental parameters: sampling waiting t...

Carbon film disk electrodes with Nafion coatings have been characterized by electrochemical impedance spectroscopy (EIS) with a view to a better understanding of their advantages and limitations in electroanalysis, particularly in anodic stripping voltammetry of metal ions. After initial examination by cyclic voltammetry, spectra were recorded over the full potential range in acetate buffer sol...

Recent clinical and pre-clinical data demonstrate that adjuvant antimicrobial therapy is beneficial in cancer treatment. For the first time, an electrochemical method was proposed for the simultaneous determination of acyclovir (ACV) and methotrexate (MTX) at activated or electropretreated pencil graphite electrode (EPPEG). Their simultaneous determination was achieved by cyclic voltammetry (CV...