Six months administration of bromocriptine mesylate significantly decreased glycated hemoglobin (HbA1c), fasting blood sugar, postprandial blood sugar, and weight of 22 Indian obese patients with type 2 diabetes mellitus with no serious adverse events. Therefore, the novel mechanism of action, efficacy and acceptable safety profile makes this drug an attractive option for treatment of obese typ...

CONTEXT Adverse drug events are common and often preventable causes of medical injuries. However, timely, nationally representative information on outpatient adverse drug events is limited. OBJECTIVE To describe the frequency and characteristics of adverse drug events that lead to emergency department visits in the United States. DESIGN, SETTING, AND PARTICIPANTS Active surveillance from Ja...

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Background: Medical errors are those mistakes committed by healthcare professionals due to wrong execution of a planned healthcare action or execution of a wrong healthcare action plan whether or not it is harmful to the patient. Medical errors may cause patients to suffer and have huge financial costs for the healthcare system. Identifying and measuring medical errors and adverse events are es...

OBJECTIVE The occurrence of drug adverse events in hospital settings is high and generates cost excess. The purpose of the study was to identify drug-related events during hospital admissions and to estimate their prevalence. METHODS A retrospective study was carried out in the State of Rio de Janeiro, Southeastern Brazil. Hospitalizations from the Brazilian Health System's national hospital ...

conclusions pain management in patients with liver dysfunction is always challenging to physicians because of the adverse reactions of drugs, especially opioids. opioids should be used cautiously since they can cause sedation, constipation and sudden encephalopathy effects. since the clearance of these drugs in patients with hepatic insufficiency is decreased, the initial dose must be decreased...

BACKGROUND The US Food and Drug Administration has operated the Adverse Event Reporting System since 1998. It collects all voluntary reports of adverse drug events submitted directly to the agency or through drug manufacturers. METHODS Using extracts published for research use, we analyzed all serious adverse drug events and medication errors in the United States reported to the Food and Drug...