Enhanced safety surveillance (ESS) was conducted in the United Kingdom and Finland for Vaxigrip and Intanza 15 µg to comply with the European Medicines Agency interim guidance aimed to detect any potential increase in reactogenicity in near real time following the annual update of the influenza vaccine strain composition. This pilot passive ESS was established to strengthen safety monitoring by...

This chapter begins with a brief review of the biological basis for development of a vaccine to prevent AIDS. Next, principles underlying the preparation of a protective vaccine are reviewed, including observations on the unprecedented hurdles posed by HIV infection compared with successful vaccines developed in the past. This chapter also discusses the biological basis for safety concerns and ...

BACKGROUND Intermittent preventive treatment of malaria in children less than five years of age (IPTc) has been investigated as a measure to control the burden of malaria in the Sahel and sub-Sahelian areas of Africa where malaria transmission is markedly seasonal. METHODS AND FINDINGS IPTc studies were identified using a systematic literature search. Meta-analysis was used to assess the prot...

To evaluate the safeties of 4 types of rabies vaccines for patients with WHO category II animal exposure, especially in different age groups.A total of 4000 patients with WHO category II animal exposure were randomly divided into 4 vaccine groups, and were respectively given with Vaccines A, B, C, and D. And subjects in each vaccine group were divided into 4 age groups (≤5, 5-18, 19-60, and ≥60...

BACKGROUND Rotavirus vaccine was licensed on August 31, 1998, and subsequently recommended for routine use among infants. To assess rare adverse events, postlicensure surveillance was conducted. OBJECTIVE To describe the cases of intussusception among rotavirus vaccine recipients reported to the Vaccine Adverse Event Reporting System from October 1998 through December 1999. SETTING AND PART...

OBJECTIVE Combination vaccines simplify vaccine administration and have the potential to promote compliance and cost-effectiveness by decreasing the number of injections needed to immunize a child. The objective of this study was to assess the safety and reactogenicity of the diphtheria-tetanus toxoid-acellular pertussis-hepatitis B virus-inactivated polio virus (DTPa-HBV-IPV) vaccine when coad...

Objective: The purpose of this study was to identify Post-Vaccination Adverse Events (PVAE) with Moderna vaccine, locally systemically, and other reactions. Methods: A quantitative descriptive research method a retrospective approach used in study. carried out at RSUD Cicalengka Bandung population employees who had received the vaccine after two complete doses Sinovac from August September 2021...

The vaccination of pigs with inactivated antigen requires adjuvanted vaccines. In general, two kinds of adjuvant are used to enhance the immunogenic properties of an antigen: aluminium salts or oil-based formulas [1, 9]. Aluminium salts often fail to induce a long-term response or a cellular immune response [7]. Emulsified vaccines are frequently used in pigs as they induce a long-lasting immun...

This paper presents a comprehensive review of the main types vaccines approaching production technology, regulatory parameters, and quality control vaccines. Bioinformatic tools computational strategies have been used in research development new pharmaceutical products, reducing time between supposed product candidates (R&D steps) final products (to be marketed). In fact, reverse vaccinolog...

Description of the eviDence collection methoD: Active searches were made on the Pubmed/MEDLINE, Scielo/LILACS and Cochrane Library databases, using the following descriptive terms (MeSH terms): Vaccines, Vaccination, Immunization, Immunization Schedule*, Immunization Programs, Mass vaccination, Vaccines, Inactivated; Vaccines Attenuated, Vaccines,Synthetic; Antiviral Agents, Antibodies, Viral; ...