Superhydrophobic and superoleophilic (SHSO) membranes have found great attention in oil–water separation application. We fabricate a SHSO stainless steel mesh-based membrane, using facile one-stage dip-coating technique, investigate the effects of silane alkyl chain size, ratio micro-to-nanoparticles coating solid fraction. Silane compounds with short- long-alkyl functional chains (Dynasylan® S...

Antibiotics are not chemically stable in water based oral pharmaceutical suspensions. Anhydrous liquid antibiotic suspension for oral administration provides a product having good shelf life and taste characteristics relative to conventional liquid formulations. A ready to use oil based cefpodoxime proxetil preparation which can be stored at room temperature was prepared and evaluated for its o...

In this study, an optimized nanodispersible oral dosage form (containing a lactate ester) was developed for cilostazol (CZL). CZL is a phosphodiesterase inhibitor used for intermittent claudication. We aimed to improve the dissolution rate and absorption of CZL giving it a better chance of oral bioavailability, and to evaluate its stability on storage. Suitable compositions of nanoemulsion prec...

The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties of Valsartan in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: amount of liquid vehicle (X1), ratio of carrier to coating material(X2) and amount of magnesium oxide(X3) on angle of repose (Y1), ha...

The main purpose of this study was to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of Olmesartan (OLM) for enhancement of its solubility and dissolution rate. In this study, liquid SNEDDS containing Olmesartan was formulated and further developed into a solid form by the spray drying technique using Aerosil 200 as a solid carrier. Based on the preliminary screening of di...

The in vitro dissolution property of slightly water soluble Fenofibrate (FN) was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of LS compacts and directly compressed tablets were studied using USP-II apparatus. Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to prod...

The aim of the present study was to design and evaluate a chronomodulated time-clock pulsatile tablets of valsartan to release it after a certain lag time, independent of the gastrointestinal pH, in its absorption window to cope with the circadian rhythm of human body for blood pressure elevation. Core tablets were prepared by direct compression of a homogenous mixture of valsartan, Avicel PH10...

The extraction of physical information from the computer simulation needs a quantitative analysis of the model. However, it is not so easily to extract the necessary characteristics from the model, especially if the model consists of thousands particles. To calculate the penetration properties, permeability or accessible volume for a given diffusiant needs the analysis of the model structure. I...

Tramadol hydrochloride, highly water soluble drug was chosen as candidate drug for formulation of controlled release drug delivery owing to its undesirable side effects like abdominal pain, anorexia which were likely to happen after administration of conventional drug delivery of tramadol. The objective of present study was to design and investigate the performance of hydrophilic and hydrophobi...