Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural synthetic superdisintegrants increase patient compliance. Methods: Direct compression adapted crospovidone, croscarmellose sodium as mucilage isolated from fruits of Abelmoschus esculentus at different concentrations along with microcrystalline cellulose aerosil. powder mi...

Levodopa continues to be the most efficacious and widely used treatment for Parkinson's disease. Levodopa dosing is understood to be critical for the optimal control of symptoms, and increasing the levodopa dose is a common method to treat advancing disease. Escalating levodopa dosages coupled with disease progression is associated with increasing likelihood of developing levodopa-induced dyski...