Wild-type Aspergillus parasiticus produces, in addition to the colorless aflatoxins, a number of pigmented secondary metabolites. Examination of these pigments demonstrated that a major component was an anthraquinone, averufanin. Radiolabeling studies with [14C]averufanin showed that 23% of the label was incorporated into aflatoxin B1 by the wild type and that 31% of the label was incorporated ...

This study was conducted to assess major Aspergillus species and aflatoxins associated with groundnut seeds and cake in Eastern Ethiopia and evaluate growers' management practices. A total of 160 groundnut seed samples from farmers' stores and 50 groundnut cake samples from cafe and restaurants were collected. Fungal isolation was done from groundnut seed samples. Aspergillus flavus was the dom...

-Aflatoxin BI was given by ip injection to year-old female guinea-pigs and 6 hr later aflatoxin B1 and its metabolites were recovered and isolated chromatographically. Approximately 14~ of the administered toxin was represented by the isolated compounds. Aflatoxin B1 and M1 each accounted for approximately 3 7o, and the remaining 94~ was a product that migrated with the solvent front in a chlor...

Aflatoxins are a group of naturally-occurring carcinogens that are known to contaminate different human and animal foodstuffs. Aflatoxin B1 (AFB1) is the most genotoxic hepatocarcinogenic compound of all of the aflatoxins. In this report, we explore the capacity of β-D-glucan (Glu) to reduce the DNA damage induced by AFB1 in mouse hepatocytes. For this purpose, we applied the comet assay to gro...

conclusions phoma glomerata pg41 strain sharing natural substrate with toxigenic a. flavus secretes metabolites possessing a significant aflatoxin-degrading activity. the activity is associated mainly with a protein-enriched high-molecular-weight fraction of extracellular metabolites and appears to be of enzymatic origin. results the afb1-degrading activity of protein-enriched fractions, isolat...

background: aflatoxin contamination of food and feed stuff is a serious health problem and significant economic concerns. in the present study, the inhibitory effect of candida parapsilosis ip1698 on mycelial growth and aflatoxin production in aflatoxigenic strains of aspergillus species was investigated. methods: mycelial growth inhibitions of nine strains of aflatoxigenic and non-aflatoxigeni...

A cohort of 18,244 mostly middle-aged (45-64 years) men residing in four small geographically defined areas of Shanghai was accrued between January 1986 and September 1989. In addition to an in-person interview regarding dietary and other past exposures, each subject donated a single void urine sample at recruitment so that the presence of aflatoxins in urine could be assessed. In addition, a 1...

Urinary excretion of 8,9-dihydro-8-(7'-guanyl)-9-hydroxyaflatoxin (AFB-Gua) was studied in areas of different liver cancer incidence in Kenya. Of 983 urine samples analysed for AFB-Gua by high-performance liquid chromatography, 12.6% gave positive results. The chemical identity of AFB-Gua was verified by synchronous scanning fluorescence spectrophotometry. A moderate degree of correlation betwe...