Social stress has been implicated as a cause of urinary bladder hypertrophy and dysfunction in humans. Using a murine model of social stress, we and others have shown that social stress leads to bladder overactivity. Here, we show that social stress leads to bladder overactivity, increased bladder compliance, and increased afferent nerve activity. In the social stress paradigm, 6-wk-old male C5...

A CENTRIPETAL impulse volley traversing the myelinated afferent fibers in the nerve to a given muscle, or fraction thereof, is known to provoke a variety of reflex effects (4). By direct, or monosynaptic impingement upon motor nuclei it promotes the discharge of homonymous motoneurons, which is to say motoneurons supplying that given muscle or muscle fraction; it facilitates the response of mot...