Aims: This article is designed to demonstrate the problems of infection in a time without antibiotics and to raise awareness and stimulate discussion about the future and the next steps for managing antibiotic resistance. Methods: Access was gained to original journals and letters of three doctors, who joined the army working as medical officers during the First World War. Transcripts of interv...

Little is known about how the minds of dead agents are represented. In the current experiment, individuals with different types of explicit afterlife beliefs were asked in an implicit interview task whether various mental state types, as well as pure biological imperatives, continue after death. The results suggest that, regardless of one’s explicit reports about personal consciousness after de...

Methods The study comprised a sub-sample of 190 healthy term infants from one centre participating in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Mode of delivery was determined from hospital records, and mothers reported infant diet at 3, 6 and 12 months postpartum. Antibiotic exposure was documented from hospital and prescription records. Gut microbiota wa...

Transforming growth factor-β (TGF-β) receptor oligomerization has important roles in signaling. Complex formation among type I and type II (TβRI and TβRII) TGF-β receptors is well characterized and is essential for signal transduction. However, studies on their interactions with the type III TGF-β coreceptor (TβRIII) in live cells and their effects on TGF-β signaling are lacking. Here we invest...

Post menopausal bleeding is one of the most common conditions referred to gynaecology departments. Up to 5% of these women are found to have malignant, or pre-malignant lesions, with early detection and investigation being crucial for curative treatment. We report on the case of a 73-year-old women referred for having regular menses since 14 years of age and discuss the current investigation an...

Transient Receptor Potential (TRP) channels form a broadly expressed and functionally diverse family of cation channels involved in various (patho)physiological processes. Whereas the mechanisms that control opening of TRP channels have been extensively studied, little is known about the transport processes of TRP channels to and within the plasma membrane. Here we used Total Internal Reflectio...

The recent report for the Commission of the European Communities on current multilingual activities in the field of scientific and technical information 1 and the 1977 conference on the same theme 2 both included substantial sections on operational and experimental machine translation systems, and in its Plan of action 3 the Commission announced its intention to introduce an operational machine...

The award of the digital dividend can consolidate auctions as the preferred mechanism for spectrum allocation. Knowing in advance an estimate of what the results of an auction with these characteristics could be would be unquestionably useful for those in charge of designing the process, even if at the end another method such as a beauty contest is chosen. This article provides a simulation of ...

New mathematical models are presented for analysis of fluorescence recovery after photobleaching (FRAP) data to account for the conical geometry of photobleaching, for spatial variations in binding of fluorescent molecules, and for directed transport of fluorescent molecules. A fast computational method for calculation of fluorescence recovery with this conical geometry is presented, and is sho...

The antioxidant activity of aqueous extracts of fresh leaves of costmary (Chrysanthemum balsamita L.) was investigated. The effect of the extraction time on total phenolic compounds (TPhC) and antioxidant activity (ABTS -, CUPRACand FRAP assays) was studied. Results demonstrated highest levels of TPhC (0.60 GAE/g fresh plant weight), CUPRAC (5.93 μMTE/g FW), ABTS (10.68 μMTE/g FW), and FRAP (7....