A newly diagnosed 5-month-old infant with cystic fibrosis (CF) developed signs and symptoms of increased intracranial pressure (ICP) within days of starting pancreatic enzyme replacement therapy. Symptoms promptly resolved on two occasions after stopping enzyme replacement. At 10 months of age, enzyme replacement was well tolerated.

STUDY OBJECTIVE To determine whether post-menopausal oestrogen use affects the risk of dying from stroke. DESIGN Postal questionnaire survey to elicit details of oestrogen replacement therapy and potential risk modifiers. SETTING Californian retirement community. PARTICIPANTS All 22,781 residents of community (white, affluent, well educated) contacted by mail and phone; 13,986 (61%, media...

PURPOSE Mechanical valve replacement is associated with complications, however, there is little information on the quality of life (QOL) of octogenarians who had undergone mechanical valve replacement at a relatively younger age. We examined survival, valve-related events, and the QOL of octogenarians who had undergone mechanical valve replacement. METHODS A total of 56 octogenarians who unde...

BACKGROUND Few studies have reported population-based outcomes for aortic valve replacement patients. METHODS Patients with severe aortic valve stenosis who underwent aortic valve replacement with or without concomitant coronary artery bypass graft surgery from January 1, 2003, to December 31, 2005, were included in the study. Statistical models were developed to identify significant risk fac...

Ochronosis or black joints disorder is a rare autosomal recessive disorder caused by deficiency of homogentisic acidoxidase. Orthopaedic manifestations are common and mostly involve spine and large joints such as knee and hip.Arthropathy is progressive and will eventually leads to arthroplasty. Not being familiar with this disorder might lead todevastating complications. We present a 57 year-ol...

Stochastic approximation (SA), a stochastic analog of iterative techniques for finding the zeroes of a function (e.g., Newton-Raphson), is applied to a problem in resource allocation, the age replacement policy (ARP) problem. A stochastically failing unit is replaced at failure or at time t, whichever comes first, under an age replacement policy. When the form of the failure distribution is unk...

The purpose of the heifer herd is to provide replacements for cows leaving the herd and to improve genetic progress. First-lactation cows significantly contribute to herd production and profit. A recommended goal for dairy replacement heifers is to calve at 24 months of age with a targeted postcalving body weight of 1250 pounds. A common misconception is that this goal is either unattainable or...

BACKGROUND AND PURPOSE High age is associated with increased postoperative mortality, but the factors that predict mortality in older hip and knee replacement recipients are not known. METHODS Preoperative clinical and operative data on 1,998 primary total hip and knee replacements performed for osteoarthritis in patients aged ≥ 75 years in a single institution were collected from a joint rep...

BACKGROUND Despite the established superiority of mitral repair over replacement, its adoption in the treatment of elderly patients has not been uniform, partly because of a lack of robust long-term survival data. We present the long-term survival of Medicare fee-for-service beneficiaries undergoing mitral valve repair and replacement over a 10-year period. METHODS AND RESULTS We used the Med...

The use of dental implants for single-tooth replacement has been established as a predictable treatment option; yet, limited data are available as to how frequently this option is recommended to patients. The aim of the present study was to examine the frequency of implant recommendation by general dental practitioners after single-tooth extraction and factors influencing their decision to reco...