Women may experience a decline in physical function during menopause. Whether this decline is due to aging or to changes in hormonal status is unknown. The authors performed a longitudinal data analysis on data collected between 1996 and 2001 to determine the effects of menopausal status, age, race, and use of hormone replacement therapy (HRT) on 3-year changes in grip and pinch strength. Parti...

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed against this burgeoning segment of the population is evidence that nonpathological aging is associated with an increased risk for cognitive decline in a variety of domains, changes that can cause mild disability even before the onset of dementia. Given that pharmacological treatments that mitigate dement...

I am fully aware of the distinction bestowed upon me to participate in tonight's meeting held to honour the memory of Sir Adolphe Abrahams. Sir Adolphe was the founder of clinical sports medicine and I for one am greatly indebted to him for much he taught me. No one before him has brought to bear upon the study of athletics the same combination of comprehensive knowledge of internal medicine an...

Most human beings experience peak physical performance in their late teens and begin a slow decline in their early 20s, whose course is greatly affected by the activity levels undertaken by individuals in the years that follow. Many studies provide evidence that in developed nations such as the U.S., a sedentary lifestyle contributes significantly to development of the major risk factors for ag...

Tanaka, Hirofumi, and Douglas R. Seals. Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. J Appl Physiol 95: 2152–2162, 2003;10.1152/japplphysiol.00320.2003.—Physiological functional capacity (PFC) is defined here as the ability to perform the physical tasks of daily life and the ease with whic...

Impairment of hippocampal-dependent spatial learning and memory with aging affects a large segment of the aged population. Hippocampal subregions (CA1, CA3, and DG) have been previously reported to express both common and specific morphological, functional, and gene/protein alterations with aging and cognitive decline. To comprehensively assess gene expression with aging and cognitive decline, ...

BACKGROUND AND AIMS Volunteer bias in intervention studies on successful aging has been poorly explored. This paper investigated differences between participants and non-participants of the Groningen Intervention Study on Successful Aging (GISSA) over a wide range of demographic, physical, psychological and social subject characteristics. METHODS Subjects were recruited among a longitudinal c...

Given the growing segment of the aging population, interest in lifestyle factors and interventions that may stimulate cognitive function in aging and may reduce the risk of age-related neurodegenerative disorders, such asAlzheimer’s disease, is increasing. The claim that physical activity enhances brain function, that is cognitive function, and is therefore associated with a reduced risk of neu...

Decline in human muscle mass and strength (sarcopenia) is one of the principal hallmarks of the aging process. Regular physical exercise and training programs are certain powerful stimuli to attenuate the physiological skeletal muscle alterations occurring during aging and contribute to promote health and well-being. Although the series of events that led to these muscle adaptations are poorly ...

Introduction: Taking into account the growth of increase in the elderly population in Iran and the world, and the emergence of the phenomenon of feminization of aging, the present study has been conducted, with aim of examining the relationship between anxiety about aging and the perceived  and experienced gender inequality among the women of Shiraz city (Iran). Methods: This cross-sectional s...