The cervix is commonly affected with various conditions including disorders of epithelial maturation, hyperplasia, benign tumors, dysplasia, and malignant neoplasms. Squamous cell carcinomas at all sites, evolve through a sequence of changes occurring in the normal squamous epithelium, ranging from dysplasia of varying degree to frank malignancy. Cell proliferation is an important feature of dy...

AIMS To evaluate whether high numbers of silver staining nucleolar organiser regions (AgNORs) in hepatocytes are associated with increased risk of hepatocellular carcinoma in chronic liver disease. METHODS The quantitative distribution of AgNORs was studied in the liver biopsy specimens of 33 patients with chronic liver disease, 11 of whom developed hepatocellular carcinoma. The interval betw...

Activation of epidermal growth factor receptor (p-EGFR) is one of the triggers in the development of many malignant tumors, and the measurement of Argentophilic Nucleolus Organizer Regions (AgNOR) area is used as a marker of tumor proliferation. Alpha actin smooth muscle (αASM) of Original Research Article Guerra et al.; BJMMR, 13(9): 1-9, 2016; Article no.BJMMR.23933 2 peritubular cells (PT) a...

The aim of this study was to evaluate the usefulness of DNA flow cytometry to determine tumor nuclear DNA index (DI), and nucleolar organizer region protein counts visualized by the argyrophil (AgNOR) technique, in confirming diagnosis and predicting clinical outcome of patients with parathyroid carcinoma (PC). We reviewed paraffin-embedded tissue sections, from 15 patients (median age 63 years...

The study consisted of morphometric analysis, assessment of the argyrophilic nucleolar organization region (AgNOR) characteristics, and image cytometry (ICM) in different tumor mass compartments: bone marrow (BM), peripheral blood (PB) and lymph nodes (LN) from patients with chronic leukemic lymphoproliferative disorders. A total of 71895 cells were analyzed on SFORM PC (VAMSTEC, Zagreb). Corre...

AIMS To investigate the relation between the numbers of interphase silver stained nucleolar organiser regions (AgNORs) and immunolabelling with the monoclonal antibody PC10, which demonstrates proliferating nuclei by reacting with proliferating cell nuclear antigen (PCNA). METHODS The established sequential technique for the demonstration of interphase AgNORs and of antigens in paraffin wax s...

by Scoville and Milner (1957), the important role of the hippocampus in the formation of memory has been extensively documented. Until now, a vast majority of actual experimental work with animals and humans has been done considering the hippocampus as a homogeneous structure with a unified functional role (Eichenbaum et al., 1999; O’Keefe et al., 1998). However, numerous studies report the mor...

In malignant lymphomas, cell kinetics has shown to be related with histologic type as well as with the clinical behaviour. The aim of our study was to investigate the relevance of cell proliferation parameters on overall survival in non-Hodgkin's lymphomas as well as their relationship with prognostic factors such as International Prognostic Index (IPI). We performed DNA-flow-cytometry (S-phase...

background: vascular endothelial growth factor (vegf) is capable of initiating angiogenesis in blood vessels and may act as mitogenic agent for epithelium of odontogenic cysts and tumors. this study was conducted to evaluate the role of epithelial vegf expression in odontogenic cysts and ameloblastoma and its correlation with argyrophilic nucleolar organizer region counts to assess its role in ...