Complement C5a is a potent inflammatory chemoattractant and might be beneficial therapeutic target for the induction of an effective anti-tumour response. agonist antagonist modulation have been demonstrated to either promote or inhibit tumour development in EMT6 murine mammary cancer cells both vitro vivo studies. For studies Alamar Blue cell viability assay was used determination, immunofluor...

Human monocytes purified by elutriation were cultured for 3 d in Teflon bags with or without human recombinant interferongamma (rIFN'y). The cells were then collected and used in suspension to determine the rate of stimulus-dependent superoxide or hydrogen peroxide formation as a measure of the NADPH-oxidase. The treatment with IFN7 increased this rate twoto threefold when phorbol myristate ace...