BACKGROUND Cystic Fibrosis (CF) lung disease is characterized by liquid hyperabsorption, airway surface dehydration, and impaired mucociliary clearance (MCC). Herein, we present a compartment-based mathematical model of the airway that extends the resolution of functional imaging data. METHODS Using functional imaging data to inform our model, we developed a system of mechanism-motivated ordi...

airway in the human respiratory system are extremely complex, ltiple-phase flows in laminar, turbulent and interactive conditions. s and fulfils the study of numerical aerosol deposition using the ay model, which is created by the image techniques from CT and This 3D reconstructed airway model represents the lung anatomy reconstructed airway model based on morphometric model. Also, de the effec...

conclusions we concluded that propofol can reduce sbp, dbp, map, hr & cough production at the time of injection but there were no significant changes in these parameters after extubation. results heart rate and blood pressure in patients receiving propofol were less than the control group (p < 0.05) at the time of injection of propofol, but there were no differences between the two groups at th...

conclusions implementing educational programs with the introduction of estimation techniques besides the use of manometer as a standard intraoperative monitoring will improve the safety of the practice. results the mean etcp after the in vitro survey was significantly lower than the mean etcp before the intervention (45 ± 13 vs. 51 ± 15 cm h2o, p = 0.002). the rate of measurements within the sa...

treacher collin’s syndrome (tcs) is a rare inherited condition characterized by bilateral and symmetric abnormalities of structures within the first and second bronchial arches. patients with tcs present a serious problem to anesthetists maintaining their airway as upper airway obstruction and difficult tracheal intubation due to severe facial deformity. because of retrognathia, airway manageme...

background: cuffed pharyngeal tube is a device designed for ventilation of anesthetized patients. cpt has advantages over face mask including: maintaining of face mask can be difficult and boring after several minutes and mobility of the practitioner is reduced due to involvement of hands. mask pressure can cause soft tissue and nerve damage around the nose. anesthetic gas leakage from the mask...

Although CSs (corticosteroids) demonstrate potent effects in the control of airway inflammation in asthma, many patients continue to experience symptoms and AHR (airway hyper-responsiveness) despite optimal treatment with these agents, probably due to progressive airway remodelling. Identifying novel therapies that can target airway remodelling and/or airway reactivity may improve symptom contr...

The concept that airway inflammation leads to airway disease has led to a widening search for the types of cellular and molecular interactions responsible for linking the initial stimulus to the final abnormality in airway function. It has not yet been possible to integrate all of this information into a single model for the development of airway inflammation and remodeling, but a useful framew...

cystic fibrosis (cf) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. more than 90% of mortality of  cf patients is due to lung complications.  healthy lungs are important for a long life for people with cf, we will discuss two important topics for maintaining respiratory health. chronic use of drug...

Airway hyperresponsiveness (AHR) is a hallmark clinical symptom of asthma. At least two components of AHR have been identified: 1) baseline AHR, which is persistent and presumably caused by airway remodelling due to chronic recurrent airway inflammation; and 2) acute and variable AHR, which is associated with an episodic increase in airway inflammation due to environmental factors such as aller...