Ample evidence to date links the phosphatidylinositol 3-kinase-regulated protein kinase Akt with the induction and progression of human cancer, including breast cancer. However, there are three Akt isoforms with limited information about their specificity during oncogenesis. This study addresses the role of the three isoforms in polyoma middle T (PyMT) and ErbB2/Neu-driven mammary adenocarcinom...

AKT1mutations occur at low frequency in a variety of solid tumors, including those of the breast and urinary bladder. Although this mutation has been shown to transform rodent cells in culture, it was found to be less oncogenic than PIK3CA mutations in breast epithelial cells. Moreover, the therapeutic potential of AKT inhibitors in human tumorswith an endogenous AKT1mutation is not known. Expr...

Our previous studies have demonstrated that the JNK signaling pathway plays an important role in ischemic brain injury and is mediated via glutamate receptor 6. Others studies have shown that N-methyl-d-aspartate (NMDA) receptor is involved in the neuroprotection of ischemic preconditioning. Here we examined whether ischemic preconditioning down-regulates activation of the mixed lineage kinase-...

The protein kinases Akt1, Akt2, and Akt3 possess nonredundant signaling properties, few of which have been investigated. Here, we present evidence for an Akt1-dependent pathway that controls interferon (IFN)-regulated gene expression and antiviral immunity. The target of this pathway is EMSY, an oncogenic interacting partner of BRCA2 that functions as a transcriptional repressor. Overexpression...

AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control study of 1,110 GCa patients and 1,114 matched cancer-free controls. We genotyped five SNPs (AKT1 rs2494750G >C, AKT1 rs2494752A >G, AKT1 rs10...

Mesenchymal cells employ actin-based membrane protrusions called podosomes and invadopodia for cross-tissue migration during normal human development such as embryogenesis and angiogenesis, and in diseases such as atherosclerosis plaque formation and cancer cell metastasis. The Akt isoforms, downstream effectors of phosphatidylinositol 3 kinase (PI3K), play crucial roles in cell migration and i...

Objective: Stanozolol is an anabolic androgenic steroid (AAS) that widely used by teenagers and athletes in bodybuilding, sports, athletics. The potential effects of stanozolol kidney functions have not been defined. In this study we investigated the expression tumor suppressor protein phosphatase tensin homolog (Pten) mRNA levels phosphatidylinositol 4,5-bisphosphate 3 kinase (Pi3k) B (Akt1) s...

Background: Double-strand breaks (DSB) are the most lethal type of DNA damage induced by ionizing radiation (IR) that repaired either non-homologous end joining (NHEJ) throughout cell cycle or homologous recombination (HR) during S phase and G2 phase. The repair IR-induced DSB through NHEJ HR is partially dependent on AKT. AKT must be present activated in nucleus immediately after irradiation t...

21 November 2006. The enzyme AKT1 has been implicated in both schizophrenia and bipolar disorder. A new study in the November 7 issue of PNAS finds that a mouse lacking the gene for AKT1 shows subtle alterations of neuronal morphology in prefrontal cortex, as well as deficits in working memory. Joseph Gogos and Maria Karayiorgou of Columbia University in New York City also report that the absen...

Although cholesterol accumulation in tumors was first reported in the early20th century, the mechanistic implications of this observation are still obscure. Here we report that caveolin-negative human prostate cancer (LNCaP) cells contain cholesterol-rich lipid rafts that mediate epidermal growth factor (EGF)-induced and constitutive signaling through the Akt1 serine-threonine kinase. EGF recep...