Introduction: Children of men with alcohol dependence are at high risk for a wide range of behavioral and neuropsychological problems. Aim: The aim of this study was to assess the psychopathology and neuropsychological characteristics of children of men with alcohol dependence syndrome. Materials and Methods: A total of 100 children (50 in the study group and 50 in the control group) were evalu...

BACKGROUND Alcohol abuse and alcoholism are leading causes of death among Native Americans. Little is known about the impact of negative childhood exposures, including parental alcoholism, childhood maltreatment, and out-of-home placement, on risk of lifetime DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th edition) diagnosis of alcohol dependence in this population. METHODS...

AIMS Circadian clock genes are involved in the development of drug-induced behaviors and regulate neurotransmission pathways in addiction. Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics. METHODS The study sample comprised of 512 individuals having alcohol dependence or alcohol abuse (according ...

BACKGROUND Non-random mating affects population variation for substance use and dependence. Developmentally, mate selection leading to positive spousal correlations for genetic similarity may result in increased risk for substance use and misuse in offspring. Mate selection varies by cohort and thus, assortative mating in one generation may produce marked changes in rates of substance use in th...

AIMS To understand current awareness of, and views on, treatment of alcohol dependence in Japan. METHODS (a) Nationwide internet-based survey of 520 individuals, consisting of 52 diagnosed alcohol-dependent (AD) persons, 154 potentially alcohol-dependent (ADP) persons, 104 family members and 106 friends/colleagues of AD persons, and 104 general individuals, derived from a consumer panel where...

American Indian/Alaska Natives have high rates of alcohol-related arrests and are overrepresented in justice systems. To understand the relationship between alcohol dependence, treatment, and alcohol-related incarceration, this study queried American Indian/Alaska Natives currently in remission from alcohol dependence. Participants reported receiving 0 to 43 treatment experiences. Moreover, par...

The annual age-standardized incidence rate of alcohol dependence among men in the Lundby community cohort prospectively observed during 1957-1972 (N = 2550) was 130 per 100,000 (including "alcohol abuse," 300 per 100,000). The individual expectancy of developing alcohol dependence in a lifetime was 8.6% (including "alcohol abuse," 19.3%). Of the cumulative probability, 78% was manifested by tho...