MORE scientific interest in the incidence of chronic alcoholism is now being shown and a "Memorandunm on Alcoholism" has recently been prepared by a Joint Committee of 'rhe British Medical Association and the Magistrates Association (1961). The need for more intensive research has been emphasized, especially into the nature and size of the problem. Assessments of the incidence of chronic alcoho...

The aim of this study was to analyse the role of differences in alcohol consumption and other risk factors for alcoholism established in late adolescence, for later differences in the distribution of alcoholism between social classes among young men. Data on risk factors in childhood and adolescence, e.g. risk use of alcohol, was collected among 49,323 men, born 1949-1951, at conscription for c...

A broad region on chromosome 4q has been linked to alcohol dependence (alcoholism). We hypothesized that such broad linkage regions represent the combined action of multiple genes. Seeking to identify genes within that region that are associated with alcoholism, we have tested the association of NFKB1, located at 4q24, with alcoholism. NFKB1 encodes a 105 kDa transcription inhibitor that is cle...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) was founded 40 years ago to help elucidate the biological underpinnings of alcohol dependence, including the potential contribution of genetic factors. Twin, adoption, and family studies conclusively demonstrated that genetic factors account for 50 to 60 percent of the variance in risk for developing alcoholism. Case-control studies...

As the number of women who use alcohol increases, so does the number of women who engage in alcohol abuse and develop alcohol dependence. The recent increased focus on women and gender differences in alcoholism research has largely come about following recognition that the face of alcoholism is changing, with alcoholism rates among men remaining stable and rising among women, particularly in yo...

Alcohol, primarily in the form of ethyl alcohol (ethanol), has occupied an important place in the history of humankind for at least 8,000 years. In most Western societies, at least 90% of people consume alcohol at some time during their lives, and 30% or more of drinkers develop alcohol-related problems. Severe alcohol-related life impairment, alcohol dependence (alcoholism), is observed at som...

OBJECTIVE to address the question of whether a mortality risk associated with depression in a 1952 representative sample of Stirling County adults changed in a new sample in 1970, and whether there was a change in associations with cigarette smoking and alcoholism. METHOD sample members were interviewed about depression and cigarette smoking. General physicians were interviewed by psychiatris...

BACKGROUND Increased alcohol consumption has been associated with depression and alcoholism, but whether these associations are causal remains unclear. We tested whether alcohol consumption is causally associated with depression and alcoholism. METHODS We included 78,154 men and women aged 20-100 years randomly selected in 1991-2010 from the general population of Copenhagen, Denmark, and geno...