Over the last few years, significant research has been conducted in the construction of artificial bone scaffolds. In the present study, different types of polymer scaffolds, such as chitosan-alginate (Chi-Alg) and chitosan-alginate with fucoidan (Chi-Alg-fucoidan), were developed by a freeze-drying method, and each was characterized as a bone graft substitute. The porosity, water uptake and re...

Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere to the oral mucosa are advantageous as they could increase the effectiveness of the therapy. Positively, negatively and neutrally charged liposomes were coated with four dif...

Soybean isoflavone (SIF) has anti-aging properties and many other biological functions; however, SIF is difficult to reach higher blood concentration due to its rapid metabolism. Therefore, it is of great value to design and produce a sustained-release formulation that is able to maintain a stable level of plasma concentrations. In this paper, soybean isoflavone sustained-release microsphere fr...

The objective of the present work was to optimize the formulation of fast disintegrating tablets (FDTs) of ondansetron HCl containing novel superdisintegrants, possessing sufficient mechanical strength and disintegration time comparable to those containing crospovidone or croscarmellose sodium. The FDTs were formulated using a novel superdisintegrant (chitosan-alginate (1:1) interpolymer comple...

Plant polyphenol compounds have been considered nutritionally important recently. However, achieving successful delivery of flavonoids and phytoestrogens via the oral route is particularly difficult, due to the formiable enzymatic and transport barriers in the gastrointestinal tract. Polymer-based delivery systems that trap molecules of interest within networks have been develpoed extensively f...

Nowadays successful regeneration of damaged bone tissue is a major problem of the reconstructive medicine and tissue engineering. Recently a great deal of attention has been focused on calcium phosphate cements (CPCs) as the effective bone fillers. Despite a number of studies regarding CPCs, only a few compare the physicochemical and biological properties of α-TCP based materials of various pha...

Meat is one of the most challenging food products in the context of maintaining quality and safety. The aim of this work was to improve the quality of raw/cooked meat by coating it with sodium alginate (A), chitosan (C), and sodium alginate-chitosan polyelectrolyte complex (PEC) hydrosols. Antioxidant properties of A, C, and PEC hydrosols were determined. Subsequently, total antioxidant capacit...

V. NAYDENOVA, V., S. VASSILEV, M. KANEVA and G. KOSTOV, 2013. Encapsulation of brewing yeast in alginate/ chitosan matrix: comparative study of beer fermentation with immobilized and free cells. Bulg. J. Agric. Sci., Supplement 2, 19: 123–127 In the present study, the possibilities for beer production with lager brewing yeasts, encapsulated in alginate/chitosan matrix with a liquid core, were i...

The catechol (1,2-dihydroxybenzene) can be oxidized by enzymatic action, and then turned into quinone. Laccase (EC 1.10.3.2) is an enzyme produced mainly by fungi of white decomposition, which contains copper, and catalyzes the oxidation of phenolic substrates by coupling the reduction of O 2 to water. The aim of this study is to evaluate the reutilization of Alginate Chitosan Laccase (ACL) bea...

The aim of this study was to determine the potential pharmaceutical applications quercetin—a natural flavonoid compound with a polyphenolic structure—following its encapsulation in polymeric microspheres resistant degradation. were prepared from compounds (chitosan and sodium alginate) via complex coacervation method, goal protecting quercetin degradation reactions that can affect bioactivity. ...