BACKGROUND The activated protein C (APC) resistance is the most common prothrombotic defect in thrombosis patients, mainly related with alterations in the F5 gene. In this work, we evaluated the presence of variants in the FV gene in Amerindian patients with deep venous thrombosis and APC resistance. METHODS A total of 87 patients with deep venous thrombosis (DVT) confirmed by Doppler ultraso...

the objective of research was to explore the suitability of lipids like compritol 888 ato and stearic acid as release retardant to develop sustained release (sr) tablets. the sr micromatrices of lipid (s) and glipizide were prepared (lm1- lm6) as intermediate product by fusion method and assessed for various pharmacotechnical properties. micromatrices were formulated as sr tablets (f1-f6) by di...

UNLABELLED Neural networks of the brain involved in the planning and execution of grasping movements are not fully understood. The network formed by macaque anterior intraparietal area (AIP) and hand area (F5) of the ventral premotor cortex is implicated strongly in the generation of grasping movements. However, the differential role of each area in this frontoparietal network is unclear. We re...

The present study investigated the genetic defects underlying severe Factor V deficiency in a 26-year-old Columbian (South America) female and her immediate family (both parents and newborn child) by next generation sequencing (NGS) of the entire F5 gene locus. Five mutations in the coding sequence of F5, including three missense single-nucleotide variants (R2102H, R513K, D107H) and two synonym...

Drugs that have narrow absorption window in the gastro-intestinal tract (GIT) will have poor absorption. For these drugs, gastro-retentive drug delivery systems offer the advantages in prolonging the gastric emptying time. Floating and sustained release tablets are developed by using a combination of hydrophilic polymer (Hydroxypropyl methylcellulose) and effervescent substance (Sodium bicarbon...

The synthesis of 2'-O-methyl-5-hydroxymethylcytidine (hm5 Cm), 5-hydroxymethylcytidine (hm5 C) and 5-formylcytidine (f5 C) phosphoramidite monomers has been developed. Optimisation of mild post-synthetic deprotection conditions enabled the synthesis of RNA containing all four naturally occurring cytosine modifications (hm5 Cm, hm5 C, f5 C plus 5-methylcytosine). Given the considerable interest ...

The homoleptic organocerium complex Ce{C(SiHMe2 )3 }3 (1) reacts with B(C6 F5 )3 to produce the zwitterionic bis(alkyl) hydridoborato Ce{C(SiHMe2 )3 }2 HB(C6 F5 )3 (2). NMR and IR spectroscopy and X-ray crystallography indicate that each alkyl ligand contains two bridging Ce↼H-Si interactions in both 1 and 2. Compound 2 serves as a precatalyst for the hydrosilylation of acrylates to give α-sily...

Self-dual codes over F5 exist for all even lengths. The smallest length for which the largest minimum weight among self-dual codes has not been determined is 24, and the largest minimum weight is either 9 or 10. In this note, we show that there exists no self-dual [24, 12, 10] code over F5, using the classification of 24-dimensional odd unimodular lattices due to Borcherds.

Objects grasped by an agent have a value not only for the acting agent, but also for an individual observing the grasping act. The value that the observer attributes to the object that is grasped can be pivotal for selecting a possible behavioral response. Mirror neurons in area F5 of the monkey premotor cortex have been suggested to play a crucial role in the understanding of action goals. How...