background: diabetes is a chronic disease that despite of medical and specific treatments has reminded as an important medical problem. various herbal were presented for treatment of diabetes. one of these plants is prosopis farcta that was used as hypoglycemic agent in traditional medicine. the aim of this study was investigation of hypoglycemic effect of prosopis farcta root in diabetes and h...

Inflammation is a response to acute tissue damage due to physical injury, infection, exposure to toxins and ischemic injury. The persistent inflammatory responses in or around developing neoplasm regulate many aspects of tumor progression. Natural plant based alkaloids are often have greater pharmacological effects and are used as medications as local anesthetic, stimulant, analgesic, anti-bact...

Rhizoma coptidis is a rhizome commonly used in traditional Chinese medicine. After oral administration of rhizoma coptidis extract, the plasma concentrations of its effective alkaloid constituents are so low that their systemic therapeutic actions cannot be explained. This study aimed to investigate the influence of lipopolysaccharide (LPS) on the pharmacokinetics of the rhizoma coptidis alkalo...

Infusions of Aspidosperma nitidum (Apocynaceae) wood bark are used to treat fever and malaria in the Amazon Region. Several species of this family are known to possess indole alkaloids and other classes of secondary metabolites, whereas terpenoids, an inositol and the indole alkaloids harmane-3 acid and braznitidumine have been described in A. nitidum . In the present study, extracts from the w...

the present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic datura stramonium (ds) seed extract as a rich source of alkaloid substances. male nmri rats were divided into control and treatment groups. the treatment rats received different doses of the ds seed extract, which was prepared from alcoholic smashed s...

BACKGROUND In vitro and in vivo antileishmanial activities of crude hydroalcoholic extract of peganum harmala seeds were investigated against Leishmania major. METHODS The extract of aerial parts of P harmala was obtained by maceration. The in vitro experiments were performed on promastigotes to assess antileishmanial activity of the extract using amphotericin B as a reference. The in vivo st...

Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the poisonous plant and characterized. Chromatographic separation of the leaf extract resulted in the isolation of swainsonine (1), 2-epi-lentiginosine (2), calystegines B(1) (3), ...

Many of the alkaloids used as drugs today are from natural sources. These drugs have been modified to produce analogs for clinical use. One of these alkaloids, pilocarpine, is an imidazole alkaloid found in plants of the genus Pilocarpus (Fig. 1). Plants of this genus are designated by the name jaborandi but only Pilocarpus microphyllus, which accumulates the highest pilocarpine content, is con...