An objective of this article is a review of contemporary knowledge on various environmental factors, that influence prevalence and course of allergic diseases, like asthma, allergic rhinitis, atopic dermatitis and also contact dermatitis. Surrounding climate may directly influence each patient, but also determines type of flora and fauna within particular geographical regions and thus affects s...

cases. Patch testing with a battery of sunscreens gave a positive reading (++) at 48 and 96 h to butyl methoxydibenzoylmethane 2% (Parsol 1789) in both cases (Fig. 1). Since only one of the sunscreens contained parsol, we decided to test with other sunscreens. The results are shown in Table 1. All sunscreens that gave a positive patch test reaction contained octocrylene, which is included in so...

The possible pathogenic role and mechanism of Di-iso-nonyl phthalate (DINP) in allergic dermatitis is still controversial. This work has shown that oral exposure to DINP exacerbated allergic dermatitis tissue lesions in FITC-sensitized mice. The lesions was accompanied by an enhancement of TRPA1 expression and an increase in IgG1, IL-6 and IL-13 levels. This work also found that blocking TRPA1 ...

BACKGROUND Oclacitinib (Apoquel(®) ) inhibits the function of a variety of pro-inflammatory, pro-allergic and pruritogenic cytokines that are dependent on Janus kinase enzyme activity. Oclacitinib selectively inhibits Janus kinase 1. HYPOTHESIS/OBJECTIVES We aimed to evaluate the safety and efficacy of oclacitinib for the control of pruritus associated with allergic dermatitis in a randomized...

E osinophilia, defined as greater than 450 eosinophils/ L, can occur in various disease processes, including infectious, allergic, neoplastic, and primary hematologic disorders. Marked eosinophilia ([1500 eosinophils/ L) can be a diagnostic dilemma because blood eosinophilia rarely exceeds 1500/ L in atopic/allergic diseases. Hyperimmunoglobulinemia E is seen in allergic, parasitic, and primary...

In 2013, we raised suspicion that cobalt in leather could be responsible for hitherto unrecognized cases of allergic contact dermatitis. We saw a patient sensitized only to cobalt with clear long-term exposure to cobalt from a leather sofa, and observed resolution of dermatitis following avoidance (1). In 2014,we performed a questionnaire study, which showed a positive and significant associati...

Diaper dermatitis is a common problem in outpatient pediatric office settings. Although most diaper rashes represent a form of contact dermatitis in response to irritants in the diaper environment, other rashes may be the result of an allergen in the diaper. On the basis of clinical examination results for 5 patients and patch testing results for 2 patients, we suspect that the patients demonst...

BACKGROUND Photocontact dermatitis to Ficus carica is induced by furocoumarins present in sap. These substances are generally considered to cause phototoxic reactions. OBJECTIVES We conducted a patch test and histopathological study of patients with phytophoto contact dermatitis from the fig tree to evaluate the mechanism underlying the photoreaction. PATIENTS AND METHODS Patch and photopat...

Preservatives used in both industrial and consumer products are well-known and important causes of contact allergy (1). The allergens relevant for this article are the preservatives methylchloroisothiazolinone (MCI) (CAS: 26172-55-4), methylisothiazolinone (MI) (CAS: 268220-4), and benzisothiazolinone (BIT) (CAS: 2634-335). MCI/MI (3:1) has been used as a preservative in cosmetics and household...

BACKGROUND: Occupational dermatitis affects the quality of life and productivity of workers. Studies on the subject are scarce in Brazil. It is estimated that the disease is underreported and that many affected patients do not seek health care. OBJECTIVES: To conduct an epidemiological analysis of occupational dermatitis notified via SINAN in Brazil from January 2007 to December 2012; evaluat...