Group II PLA 2 has been implicated in inflammatory processes in both man and other animals and has been shown to be involved in inflammatory conditions, such as arthritis and sepsis. Transgenic mice expressing the human group II PLA 2 gene have been generated using a 6.2-kb genomic fragment. These mice express the group II PLA 2 gene abundantly in liver, lung, kidney, and skin, and have serum P...

Ectodermal dysplasias are a large group of heterogeneous heritable conditions characterized by congenital defects of ectodermal structures and their appendages: hair (hypotrichosis, partial or total alopecia), nails (dystrophic, hypertrophic, abnormally keratinized), teeth (enamel defect or absent) and sweat glands (hypoplastic or aplastic). The ectodermal dysplasias, as a rule, are not pure “o...

Down syndrome (DS) is the most common chromosomal abnormality in humans, and the most frequent cause of mental retardation. Patients affected by this syndrome show an increased prevalence of autoimmune diseases. The most common of those is Hypothyroidism. We present a case report describing the association of Down syndrome with Hyperthyroidism. An 18-year-old patient presented with a history of...

We present a case of cystic lymphangioma of the mediastinum complicated with situs inversus totalis. The 70-year-old man underwent thoracoscopic resection of a mediastinal cystic tumor, which was diagnosed as cystic lymphangioma. Cystic lymphangiomas are congenital cystic abnormalities of the lymphatic system. The head and neck area is often involved while the mediastinum is rarely affected. Th...

RATIONALE Situs inversus totalis is a rare anomaly disease in which the organs in the chest and abdomen are positioned in a mirror image reversal of normal positions. Although this has been confirmed to be associated with spinal abnormalities, reports about situs inversus totalis with congenital scoliosis remain limited. PATIENT CONCERNS We present a 9-year-old girl having congenital scoliosi...

Situs inversus totalis is a rare anomaly that is characterized by mirror image anatomy of the abdominal and thoracic organs. This anomaly is often discovered incidentally in adults during an emergent surgical procedure or by radiologic investigations performed for other medical reasons. Cecal volvulus is a surgical emergency requiring urgent laparotomy. Coexistence of these two abnormalities po...

Recent evidence indicates that periodontitis is associated with immune-mediated cutaneous and systemic inflammatory disorders, such as psoriasis, lupus erythematosus rheumatoid arthritis. Although a few cases of alopecia areata (AA) dental origin have been reported, the association between AA has never studied. Therefore, we investigated whether increases risk by using National Health Insurance...

Situs inversus totalis is a rare condition where the visceral organs are organized as a mirror image of default organ position. In this study we picture the co-development between brain and visceral organs in a case of situs inversus totalis from a fetal stage to adolescence and compare our findings to an age-, gender-, and education-matched control with normal position of thoracic and abdomina...

Situs inversus totalis is is a congenital anomaly associated with various visceral abnormalities, but there is no data about the relationship between secondary biliary cirrhosis and that condition. We here present a case of a 58 year-old female with situs inversus totalis who was admitted to our clinic with extrahepatic cholestasis. After excluding all potential causes of biliary cirrhosis, sec...