Lipoic acid-dependent pathways of alpha-keto acid oxidation by mitochondria were investigated in pea (Pisum sativum), rice (Oryza sativa), and Arabidopsis. Proteins containing covalently bound lipoic acid were identified on isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis separations of mitochondrial proteins by the use of antibodies raised to this cofactor. All th...

The present study was designed to evaluate the influence of alpha-lipoic acid treatment in rats exposed to malathion. Forty adult male rats were used in this study and distributed into four groups. Animals of group 1 were untreated and served as control. Rats of group 2 were orally given malathion at a dose level of 100 mg/kg body weight (BW) for a period of one month. Experimental animals of g...

Tinnitus is one of the most prevalent and annoying disorders that affect ear auditory system. It important symptoms in neurootology, along with hearing loss, vertigo, dizziness, nausea. can cause a variety somatic psychological interfere person's quality life. There correlation between oxidative stress tinnitus. Hair cell apoptosis, cochlear degeneration, alterations to supporting structures st...

The article presents current data from the scientific medical literature on effective use of R(+)-enantiomer α-lipoic acid in various pathological conditions. authors analyze comparative assessment activity racemic and dextrorotatory forms thioctic (alpha-lipoic) low back pain, effect combination with hyperbaric oxygen therapy production interleukin-6, tumor necrosis factor α vascular endotheli...

Blinding cataract is a significant effect of canine diabetes with 75% of animals affected two years after diagnosis. Lens opacification occurs primarily through the generation of sorbitol, a sugar alcohol, through the action of aldose reductase (AR). The osmotic effect of sorbitol draws water into the lens, causing opacification. Inhibition of AR should thus prevent the generation of cataracts....

UNLABELLED Burning Mouth Syndrome (BMS) is a disease that manifests as burning in the tongue or in any area of the oral mucosa, in the absence of clinically verifiable injuries. OBJECTIVES To verify the efficacy of alpha lipoic acid (ALA) and gabapentin (GABA), used individually and jointly, to reduce the burning in patients with burning mouth and establish a drug therapy for the BMS. STUDY...

DA-9801, a mixture of extracts from Dioscorea japonica Thunb. and Dioscorea nipponica Makino, was reported to have neurotrophic activity. Therefore, we investigated the therapeutic potential of DA-9801, in comparison with alpha lipoic acid (ALA), for peripheral nerves preservation in experimental diabetes. Experimental animals were divided into 4 groups, and each group was designated according ...