The combined effects of low-dose or high-dose alpha particles and depleted uranium (DU) in Zebrafish (Danio rerio) embryos were studied. Three schemes were examined-(i) [ILUL]: 0.44 mGy alpha-particle dose + 10 µg/l DU exposure, (ii) [IHUH]: 4.4 mGy alpha-particle dose + 100 µg/l DU exposure and (iii) [IHUL]: 4.4 mGy alpha-particle dose + 10 µg/l DU exposure-in which Zebrafish embryos were irra...

The activity concentration of gross alpha and gross beta particles in four samples of borehole drinking water consumed in Ibrahim Badamasi Babangida University (IBBU), Lapai, Niger State-Nigeria was measured, using a portable single channel gas free proportional counter (MPC2000B-DP) detector. This study focused on cancer related problems and the bio-data of the environment was discussed as wel...

Our aim was to characterize HDL subspecies and fat-soluble vitamin levels in a kindred with familial apolipoprotein A-I (apoA-I) deficiency. Sequencing of the APOA1 gene revealed a nonsense mutation at codon -2, Q[-2]X, with two documented homozygotes, eight heterozygotes, and two normal subjects in the kindred. Homozygotes presented markedly decreased HDL cholesterol levels, undetectable plasm...

The decay of excited 0 projectiles into the four alpha particle exit channel has been investigated. The projectiles, with bombarding energies of E/A = 25 MeV, were excited through peripheral interactions with ' Tb target nuclei. A 4' counter was used to detect both the projectile alpha particles and the light charged particles evaporated from the target nucleus. Criteria for selecting true 0~4o...

Flock house virus (FHV) is a small icosahedral insect virus of the family Nodaviridae. Its genome consists of two messenger-sense RNA molecules, both of which are encapsidated in the same particle. RNA1 (3.1 kb) encodes proteins required for viral RNA replication; RNA2 (1.4 kb) encodes protein alpha (43 kDa), the precursor of the coat protein. When Spodoptera frugiperda cells were infected with...

The mutagenicity of 4-methylnitrosamine-1-3-pyridyl-1-butanone (NNK), either alone or in combination with low dose alpha particle irradiation, was examined using the human-hamster hybrid (A(L)) cell assay. NNK induced a dose-dependent toxicity in A(L) cells. In combination with a 25 cGy dose of alpha particles, the induced survival fraction fell within the statistical range of the calculated va...

The inflammatory response is a key component of host defense. However, excessive or persistent inflammation can contribute to the pathogenesis of disease. Inflammation is regulated, in part, by cytokines, which are small, typically glycosylated proteins that interact with membrane receptors to regulate cellular processes such as proliferation, differentiation, and secretion. During the past 10 ...

The ionization produced by the Li7* and o<-particles from the reaction BlO(njo<)Li7* as they were stopped in argonj argon-nitrogen~ and argoncarbon dioxide gas mixtures was measured. A gridded parallel-plate ionization chamber employing electron collection was used. Plutonium alpha particles were used for calibration and the ionization electron pulses were amplified and sorted-with an electroni...

PURPOSE Technetium-99m (99mTc) has been widely used as an imaging agent but only recently has been considered for therapeutic applications. This study aims to analyze the potential use of 99mTc Auger electrons for targeted tumor radiotherapy by evaluating the DNA damage and its probability of correct repair and by studying the cellular kinetics, following 99mTc Auger electron irradiation in com...