Earlier studies have demonstrated that aldose reductase (AR) plays a key role in mediating ischemia-reperfusion (I/R) injury. Our objective was to investigate if AR mediates I/R injury by influencing phosphorylation of glycogen synthase kinase-3β (p-GSK3β). To investigate this issue, we used three separate models to study the effects of stress injury on the heart. Hearts isolated from wild-type...

The toxicity of Ustilago maydis and the possible synergism with fumonisin B1 (FB1) were studied in Fischer rats by evaluating pathological changes and biochemical parameters in blood serum (LDH, ALT, GGT, ChE) and tissue homogenate of brain and liver (AChE, ChE, GGT, ALP). One experimental group (US) consumed diet with 70% of U. maydis galls and the other group (US+FB1) was fed pellets containi...

28 29 Objective: Earlier studies have demonstrated that aldose reductase (AR) plays a key role in 30 mediating ischemia-reperfusion (I/R) injury. Our objective was to investigate if AR mediates I/R 31 injury by influencing phosphorylation of glycogen synthase kinase 3β (p-GSK3β). 32 Methods: We utilized three separate models to study the effects of stress injury on the heart. 33 Hearts isolated...

Abbreviations used: ALT, Alanine aminotransferase; ApoB, Apolipoprotein B; AST, Aspartate aminotransferase; ER, Endoplasmic Reticulum; GPT, Glutamic Pyruvic Transaminase; GOT, Glutamic Oxaloacetic Transaminase; GSH, Reduced glutathione; HDL, High density lipoprotein; HMGR, HMG-CoA reductase; LDH, lactate dehydrogenase; Lo, Lovastatin; MTP, Microsomal triglycerides transfer protein; MTPi, MTP in...

Abstract Background The levels of serum D-dimer (D-D) in children with Mycoplasma pneumoniae pneumonia (MPP) were assessed to explore the clinical significance D-D refractory MPP (RMPP). Method A total 430 patients enrolled between January 2015 and December divided into a general (GMPP) group ( n = 306) RMPP 124). Clinical data, level, white blood cell (WBC) count, proportion neutrophils (N%), ...

Pneumatic tube systems of various lengths are routinely used in many hospitals to transport blood collection tubes (serum, plasma, whole blood) to the testing laboratory. The present study evaluated the changes in the levels of enzymes in two different tube system transports within the hospital system. Two tubes of blood, one SST (Serum) tube and one Lithium Heparin (Plasma) tube, were collecte...

OBJECTIVE This study was performed to determine the occurrence of hypoxic hepatitis in full-term neonates after perinatal asphyxia and to correlate between the rise in enzymes and severity of asphyxia with Apgar score and hypoxic ischemic encephalopathy (HIE) grading of the neonates. METHOD AND MATERIAL This prospective case-controlled study was conducted in a tertiary-level hospital in India...