OBJECTIVE We developed visual motion evoked potential (EP) measures related to navigational impairment in Alzheimer disease (AD) and have now applied these methods to explore the role of elementary perceptual and attentional mechanisms mediating these effects. METHODS Older adult (OA) control subjects and AD patients underwent visual motion perceptual testing, attentional performance monitori...

alzheimer disease is one form of dementia in old age. alzheimer disease, the incurable disease, which is usually in the seventh decade of human life, shows its symptoms. the disease may be present for years without clinical symptoms. the current study identified the genes with altered expression in patients with alzheimer disease. the important sequence of each gene in alzheimer disease was fou...

In this paper we present a novel method for automatic classification of MR Images into the categories of Normal and Alzheimer's disease (AD), which is then further classified into the severity of the neurological problem. In recent years, with all the advancement happening all over, humans suffer from various neurological disorders such as Epilepsy, Alzheimer, Multiple sclerosis, etc. Alzheimer...

Vascular involvement in Alzheimer disease (AD) is not necessarily coincident. Current evidence suggests the neuropathology of Alzheimer type of dementia comprises more than amyloid plaques and neurofibrillary tangles. At least a third of recognized AD cases may exhibit cerebrovascular pathology, which also constitutes distinct small vessel disease. Cerebral amyloid angiopathy, microvascular deg...

BACKGROUND Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials. OBJECTIVE To determine whether functional magnetic resonance imaging can reliably distinguish risk groups for AD among cognitively normal middle-aged adults. DESIGN Cross-sectional case-control study. ...

BACKGROUND Magnetic resonance imaging (MRI) can aid clinical assessment of brain changes potentially correlated with Alzheimer disease (AD). MRI traits may improve our ability to identify genes associated with AD-outcomes. We evaluated semi-quantitative MRI measures as endophenotypes for genetic studies by assessing their association with AD in families from the Multi-Institutional Research in ...

some animal models have been used to study alzheimer's disease (ad). ad is an irreversible progressive neurodegenerative disease and the most common cause of dementia. animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of meynert (nbm) and loss of learning capability and memory. the aim of this study was to investigate the ef...

Overview- One hundred and ten years since its first description Alzheimer's disease (AD) still retains its prominent status: (i) as the industrialized world's number one cause of age-related intellectual impairment and cognitive decline; (ii) as this country's most rapidly expanding socioeconomic and healthcare concern; and (iii) as an insidious, progressive and lethal neurological disorder of ...

In this work we consider marketed drugs for Alzheimer disease (AD) including acetylcholinesterase inhibitors (AChE-Is) and antiglutamatergic treatment involving the N-methyl-d-aspartate (NMDA) receptor. We discuss medications and substances available for use as cognitive enhancers that are not approved for AD or cognitive impairment, and other neurotransmitter-related therapies in development o...

BACKGROUND Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders. OBJECTIVE To determine the relationship of GBA mutations and APOE4 genotype to LB and Alzheimer disease (AD) pathological findings. DESIGN Case-control study. SETTING Academic research. PARTICIPANTS The 187 subjects included patients with primary neuropathological diagnoses of LB diso...