Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiolo...

Current research is aiming to push the boundaries of the point at which a diagnosis of Alzheimer Disease (AD) can be made. Clinical syndromes such as Mild Cognitive Impairment (MCI) and various clinical and biological markers of AD may help to identify people in the early stage of AD, before a full dementia syndrome is present. In the first part of this paper, we discuss whether MCI represents ...

background: family caregivers usually report the reduction of their life quality due to one of the family member’s spinal cord injury. thus, the present study aimed to investigate the effectiveness of psycho-educational interventions on the life quality of the family caregivers of the patients with spinal cord injury. methods: the present randomized controlled trial was conducted on 72 family c...

impact of psychoeducational groups for caregivers on the psychiatric symptoms of patients with schizophrenia     shaygan m [1] *, sharif f [2]     received: 21 nov, 2012 accepted: 11 feb , 2013     abstract:   background & aims : schizophrenia is a severe psychiatric disorder, which is extremely stressful not only for the persons affected but also for their families.   materials & methods : to ...

AIM To examine factors associated with family caregivers' choice of care setting (own home vs. nursing home) for their relatives with dementia. METHODS Cross-sectional study involving caregivers recruited from a tertiary hospital dementia clinic and the local Alzheimer's association. Caregivers completed a questionnaire containing demographics of the person with dementia (PWD) and caregiver, ...

alzheimer disease is one form of dementia in old age. alzheimer disease, the incurable disease, which is usually in the seventh decade of human life, shows its symptoms. the disease may be present for years without clinical symptoms. the current study identified the genes with altered expression in patients with alzheimer disease. the important sequence of each gene in alzheimer disease was fou...

Black caregivers of persons with Alzheimer disease and related dementias (ADRD) have demonstrated significantly lower levels of stress and burden than white caregivers, as measured by instruments that assess caregiving burden and stressfulness of specific problem behaviors. However, the reasons for reported differences are unclear and cannot be attributed solely to race. This descriptive study ...

This study describes the development and validation of the Activities of Daily Living Questionnaire (ADLQ), an informant-based assessment of functional abilities, in patients with probable Alzheimer disease and other forms of dementia. The ADLQ measures functioning in six areas: self-care, household care, employment and recreation, shopping and money, travel, and communication. The ADLQ was adm...