Positron Emission Tomography (PET) scan images are one of the bio medical imaging techniques similar to that of MRI scan images but PET scan images are helpful in finding the development of tumors. The PET scan images requires expertise in the segmentation where clustering plays an important role in the automation process. The segmentation of such images is manual to automate the process cluste...

Alzheimer’s disease (AD) is a devastating neurodegenerative disease with no current cure. FDA approved drugs have been widely used to address symptoms of AD, but none have been successful in preventing or reversing its effects. As the prevalence of AD increases due to the increased lifespan of the population, it is becoming essential to discover new drugs or find alternative treatment approache...

Memory is the ability of an individual to record the information and recall it whenever needed. Dementia is a mental disorder characterized by loss of intellectual ability (judgment or abstract thinking) which invariably involves impairment of memory. The most common cause of dementia is Alzheimers disease (AD), which is a progressive neurodegenerative disorder associated with loss of neurons i...

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the most popular animal models of alzheimer’s disease (ad) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. an increasing number of genetic, vascular and psychosocial data strongly support that the octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the ...

OBJECTIVES Preclinical Alzheimers disease (AD) patients may or may not show cognitive impairment on testing. AD biomarkers are central to the identification of those at low, intermediate, or high risk of later dementia due to AD. We investigated biomarker distribution in those identified as subjective cognitive decline (SCD), amnestic (aMCI), and nonamnestic (naMCI) mild cognitive impairment (M...

alzheimer’s disease (ad) is the most common cause of dementia caused by complicated interactions between genetic and environmental factors. molecular genetic research has provided valuable information regarding the genetic etiology of the disease. identifying the genetics of ad not only could shed light on disease pathogenesis, but it may also provide potential targets for effective treatment, ...

Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in...

BACKGROUND Alzheimers disease (AD) has been strongly linked to an anomalous self-assembly of the amyloid-β peptide (Aβ). The correlation between clinical symptoms of AD and Aβ depositions is, however, weak. Instead small and soluble Aβ oligomers are suggested to exert the major pathological effects. In strong support of this notion, immunological targeting of Aβ oligomers in AD mice-models show...